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Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [ Mus musculus (house mouse) ]

Gene ID: 18019, updated on 25-Nov-2021

Summary

Official Symbol
Nfatc2provided by MGI
Official Full Name
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2provided by MGI
Primary source
MGI:MGI:102463
See related
Ensembl:ENSMUSG00000027544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NFAT1; Nfatp; NF-ATp; NF-ATc2; NFAT1-D; AI607462
Expression
Broad expression in spleen adult (RPKM 4.4), thymus adult (RPKM 3.6) and 24 other tissues See more
Orthologs
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Genomic context

See Nfatc2 in Genome Data Viewer
Location:
2 H3; 2 88.91 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168318330..168443900, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168476410..168601657, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (168301910..168427155, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33262 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 33413 Neighboring gene microRNA 7004 Neighboring gene ATPase, class II, type 9A Neighboring gene VISTA enhancer mm1375

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within calcineurin-NFAT signaling cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myotube cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor AP-1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
nuclear factor of activated T-cells, cytoplasmic 2
Names
NFAT pre-existing subunit
T-cell transcription factor NFAT1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037177.2NP_001032254.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform b

    See identical proteins and their annotated locations for NP_001032254.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as IB-IIL-VIIa) lacks four 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK135414, AW049827, EU887600
    Consensus CDS
    CCDS17113.1
    UniProtKB/TrEMBL
    B5B2R5
    Related
    ENSMUSP00000029057.6, ENSMUST00000029057.13
    Conserved Domains (2) summary
    cd07881
    Location:400574
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:579618
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. NM_001037178.2NP_001032255.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform c

    See identical proteins and their annotated locations for NP_001032255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as IA-IIS-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 3 and 16 encode isoform c.
    Source sequence(s)
    AK044489, AW049827, EU887601
    Consensus CDS
    CCDS17114.1
    UniProtKB/TrEMBL
    Q8C443
    Related
    ENSMUSP00000130875.2, ENSMUST00000171689.8
    Conserved Domains (2) summary
    cd07881
    Location:179353
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:358397
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  3. NM_001136073.2NP_001129545.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform d

    See identical proteins and their annotated locations for NP_001129545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as IB-IIL-Xa) contains an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK135414, BP757417, EU887582
    Consensus CDS
    CCDS50803.1
    UniProtKB/TrEMBL
    B5B2P7
    Related
    ENSMUSP00000104812.2, ENSMUST00000109184.8
    Conserved Domains (2) summary
    cd07881
    Location:400574
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:579679
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  4. NM_001291168.1NP_001278097.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform e

    See identical proteins and their annotated locations for NP_001278097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as IA-IIL-deltaXa) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK044489, BP757417, EU887585, EU887587
    UniProtKB/TrEMBL
    B5B2Q2, Q3TTU8
    Conserved Domains (2) summary
    cd07881
    Location:380554
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:559659
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  5. NM_001291169.1NP_001278098.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform f

    See identical proteins and their annotated locations for NP_001278098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6, also known as IA-deltaII-Xa) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also contains an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AK044489, BP757417, EU887581
    UniProtKB/TrEMBL
    B5B2P6
    Conserved Domains (2) summary
    cd07881
    Location:380554
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:559659
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  6. NM_001291170.1NP_001278099.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform g

    See identical proteins and their annotated locations for NP_001278099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7, also known as IA-IIS-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (g) is shorter at the N-terminus, compared to isoform a. Both variants 7 and 14 encode isoform g.
    Source sequence(s)
    AK044489, BP757417, EU887585, EU887589
    UniProtKB/TrEMBL
    B5B2Q4, Q3TTU8
    Conserved Domains (2) summary
    cd07881
    Location:179353
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:358458
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  7. NM_001291171.1NP_001278100.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform h

    See identical proteins and their annotated locations for NP_001278100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8, also known as IA-deltaII-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter at at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 8 and 13 encode isoform h.
    Source sequence(s)
    AK044489, BP757417, EU887585
    UniProtKB/TrEMBL
    Q3TTU8
    Related
    ENSMUST00000151292.8
    Conserved Domains (2) summary
    cd01178
    Location:129229
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl08275
    Location:1124
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
  8. NM_001291172.1NP_001278101.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform i

    See identical proteins and their annotated locations for NP_001278101.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9, also known as IA-IIL-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (i) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AK044489, AW049827, EU887599
    Consensus CDS
    CCDS71201.1
    UniProtKB/TrEMBL
    A2AQC8
    Related
    ENSMUSP00000118329.2, ENSMUST00000137451.2
    Conserved Domains (2) summary
    cd07881
    Location:380554
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:559598
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  9. NM_001291173.1NP_001278102.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform j

    See identical proteins and their annotated locations for NP_001278102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10, also known as IA-deltaII-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (j) is shorter at the N-terminus, compared to isoform a. Both variants 10 and 15 encode isoform j.
    Source sequence(s)
    AK044489, BP757417, EU887585, EU887591
    UniProtKB/TrEMBL
    B5B2Q6, Q3TTU8
    Conserved Domains (2) summary
    cd01178
    Location:129229
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl08275
    Location:1124
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
  10. NM_001291174.1NP_001278103.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform k

    See identical proteins and their annotated locations for NP_001278103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11, also known as IA-IIS-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (k) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 11 and 12 encode isoform k.
    Source sequence(s)
    AK044489, BP757417, EU887583
    UniProtKB/TrEMBL
    B5B2P8
    Conserved Domains (2) summary
    cd07881
    Location:179353
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:358458
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  11. NM_001291175.1NP_001278104.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform k

    See identical proteins and their annotated locations for NP_001278104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12, also known as IB-IIS-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (k) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 11 and 12 encode isoform k.
    Source sequence(s)
    AK135414, BP757417, EU887584
    UniProtKB/TrEMBL
    B5B2P8
    Conserved Domains (2) summary
    cd07881
    Location:179353
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:358458
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  12. NM_001291176.1NP_001278105.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform h

    See identical proteins and their annotated locations for NP_001278105.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13, also known as IB-deltaII-Xa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter at at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 8 and 13 encode isoform h.
    Source sequence(s)
    AK135414, BP757417, EU887586
    UniProtKB/TrEMBL
    Q3TTU8
    Conserved Domains (2) summary
    cd01178
    Location:129229
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl08275
    Location:1124
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
  13. NM_001291177.1NP_001278106.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform g

    See identical proteins and their annotated locations for NP_001278106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14, also known as IB-IIS-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (g) is shorter at the N-terminus, compared to isoform a. Both variants 7 and 14 encode isoform g.
    Source sequence(s)
    AK135414, BP757417, EU887581, EU887590
    UniProtKB/TrEMBL
    B5B2P6, B5B2Q4
    Conserved Domains (2) summary
    cd07881
    Location:179353
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:358458
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  14. NM_001291178.1NP_001278107.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform j

    See identical proteins and their annotated locations for NP_001278107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15, also known as IB-deltaII-deltaXa) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (j) is shorter at the N-terminus, compared to isoform a. Both variants 10 and 15 encode isoform j.
    Source sequence(s)
    AK135414, BP757417, EU887581, EU887592
    UniProtKB/TrEMBL
    B5B2P6, B5B2Q6
    Conserved Domains (2) summary
    cd01178
    Location:129229
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl08275
    Location:1124
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
  15. NM_001291179.1NP_001278108.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform c

    See identical proteins and their annotated locations for NP_001278108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16, also known as IB-IIS-VIIa) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a. Both variants 2 and 16 encode isoform c.
    Source sequence(s)
    AK135414, AW049827, EU887602
    Consensus CDS
    CCDS17114.1
    UniProtKB/TrEMBL
    Q8C443
    Conserved Domains (2) summary
    cd07881
    Location:179353
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:358397
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  16. NM_010899.3NP_035029.2  nuclear factor of activated T-cells, cytoplasmic 2 isoform a

    See identical proteins and their annotated locations for NP_035029.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as IB-IIL-deltaXa) encodes the longest isoform (a).
    Source sequence(s)
    AK135414, BP757417, EU887581, EU887588
    Consensus CDS
    CCDS17112.1
    UniProtKB/Swiss-Prot
    Q60591
    UniProtKB/TrEMBL
    B5B2P6
    Related
    ENSMUSP00000074198.4, ENSMUST00000074618.10
    Conserved Domains (2) summary
    cd07881
    Location:400574
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:579679
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

RNA

  1. NR_111897.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17, also known as IA-deltaII-VIIa) contains alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK044489, AW049827, EU887603
  2. NR_111898.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18, also known as IB-deltaII-VIIa) contains alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK135414, AW049827, EU887604

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    168318330..168443900 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159313.1XP_036015206.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1

    Conserved Domains (2) summary
    cd01178
    Location:261361
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    cl08275
    Location:128256
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
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