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DPEP1 dipeptidase 1 [ Homo sapiens (human) ]

Gene ID: 1800, updated on 6-Sep-2021

Summary

Official Symbol
DPEP1provided by HGNC
Official Full Name
dipeptidase 1provided by HGNC
Primary source
HGNC:HGNC:3002
See related
Ensembl:ENSG00000015413 MIM:179780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDP; RDP; MBD1
Summary
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]
Expression
Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues See more
Orthologs
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Genomic context

See DPEP1 in Genome Data Viewer
Location:
16q24.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (89613308..89641540)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89679716..89704841)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 68 Neighboring gene ribosomal protein L13 Neighboring gene copine 7 Neighboring gene charged multivesicular body protein 1A Neighboring gene spermatogenesis associated 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GPI anchor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables beta-lactamase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallodipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloexopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables modified amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in antibiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular lactam catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to nitric oxide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutathione catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glutathione metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in homocysteine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukotriene metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
dipeptidase 1
Names
beta-lactamase
dehydropeptidase-I
dipeptidase 1 (renal)
hRDP
microsomal dipeptidase
renal dipeptidase
testicular tissue protein Li 57
NP_001121613.1
NP_001376395.1
NP_001376396.1
NP_001376397.1
NP_001376398.1
NP_001376399.1
NP_001376400.1
NP_004404.1
XP_024305941.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128141.3NP_001121613.1  dipeptidase 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001121613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3-6, encodes isoform a.
    Source sequence(s)
    AC010538, BC017023, BM152944
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    P16444
    UniProtKB/TrEMBL
    A0A140VJI3
    Related
    ENSP00000397313.1, ENST00000421184.5
    Conserved Domains (1) summary
    pfam01244
    Location:26352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  2. NM_001389466.1NP_001376395.1  dipeptidase 1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, and 4-6, encodes isoform a.
    Source sequence(s)
    AC010538
    Related
    ENST00000564281.5
    Conserved Domains (1) summary
    pfam01244
    Location:26352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  3. NM_001389467.1NP_001376396.1  dipeptidase 1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3, 5, and 6, encodes isoform a.
    Source sequence(s)
    AC010538
    Conserved Domains (1) summary
    pfam01244
    Location:26352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  4. NM_001389468.1NP_001376397.1  dipeptidase 1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4 and 6, encodes isoform a.
    Source sequence(s)
    AC010538
    Conserved Domains (1) summary
    pfam01244
    Location:26352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  5. NM_001389469.1NP_001376398.1  dipeptidase 1 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1-5, encodes isoform a.
    Source sequence(s)
    AC010538, BC017023
    Related
    ENSP00000261615.4, ENST00000261615.5
    Conserved Domains (1) summary
    pfam01244
    Location:26352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  6. NM_001389470.1NP_001376399.1  dipeptidase 1 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform b.
    Source sequence(s)
    AC010538
    Conserved Domains (1) summary
    pfam01244
    Location:26352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  7. NM_001389471.1NP_001376400.1  dipeptidase 1 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform b.
    Source sequence(s)
    AC010538
    Conserved Domains (1) summary
    pfam01244
    Location:26352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  8. NM_004413.4NP_004404.1  dipeptidase 1 isoform a precursor

    See identical proteins and their annotated locations for NP_004404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2-6, encodes isoform a.
    Source sequence(s)
    AC010538, BC017023, J05257
    Consensus CDS
    CCDS10982.1
    UniProtKB/Swiss-Prot
    P16444
    UniProtKB/TrEMBL
    A0A140VJI3
    Related
    ENSP00000376807.3, ENST00000393092.7
    Conserved Domains (1) summary
    pfam01244
    Location:26352
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    89613308..89641540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450173.1XP_024305941.1  dipeptidase 1 isoform X2

    Conserved Domains (1) summary
    pfam01244
    Location:5307
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
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