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Nab2 Ngfi-A binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 17937, updated on 8-Feb-2024

Summary

Official Symbol
Nab2provided by MGI
Official Full Name
Ngfi-A binding protein 2provided by MGI
Primary source
MGI:MGI:107563
See related
Ensembl:ENSMUSG00000025402 AllianceGenome:MGI:107563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity and transcription coregulator activity. Acts upstream of or within several processes, including endochondral ossification; nervous system development; and regulation of epidermis development. Located in nucleus. Is expressed in future hindbrain and genitourinary system. Orthologous to human NAB2 (NGFI-A binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 34.3), thymus adult (RPKM 23.8) and 28 other tissues See more
Orthologs
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Genomic context

See Nab2 in Genome Data Viewer
Location:
10 D3; 10 74.6 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127496787..127502572, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127660918..127666703, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40802 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127078975-127079084 Neighboring gene signal transducer and activator of transcription 6 Neighboring gene predicted gene, 30989 Neighboring gene STARR-positive B cell enhancer mm9_chr10:127099117-127099417 Neighboring gene RIKEN cDNA 1700012D01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127105871-127106058 Neighboring gene STARR-positive B cell enhancer ABC_E2971 Neighboring gene predicted gene 16230 Neighboring gene STARR-positive B cell enhancer ABC_E1133

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NGFI-A-binding protein 2
Names
EGR-1-binding protein 2
NGFI-A binding protein 2 (EGR-1 binding protein 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122895.1NP_001116367.1  NGFI-A-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001116367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC045139, BY160550
    Consensus CDS
    CCDS48719.1
    UniProtKB/TrEMBL
    Q3TBL2, Q3TYF1
    Related
    ENSMUSP00000096761.4, ENSMUST00000099157.4
    Conserved Domains (2) summary
    pfam04904
    Location:37114
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:235364
    NCD2; NAB conserved region 2 (NCD2)
  2. NM_008668.2NP_032694.2  NGFI-A-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_032694.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC045139, BY160550
    Consensus CDS
    CCDS24247.1
    UniProtKB/Swiss-Prot
    Q61127, Q80VR9
    UniProtKB/TrEMBL
    Q3TBL2
    Related
    ENSMUSP00000026469.3, ENSMUST00000026469.9
    Conserved Domains (2) summary
    pfam04904
    Location:37114
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:235364
    NCD2; NAB conserved region 2 (NCD2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127496787..127502572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)