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Myo6 myosin VI [ Mus musculus (house mouse) ]

Gene ID: 17920, updated on 18-Apr-2024

Summary

Official Symbol
Myo6provided by MGI
Official Full Name
myosin VIprovided by MGI
Primary source
MGI:MGI:104785
See related
Ensembl:ENSMUSG00000033577 AllianceGenome:MGI:104785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sv; Tlc; rsv; Myo6<rsv>
Summary
Predicted to enable actin filament binding activity; identical protein binding activity; and microfilament motor activity. Involved in postsynaptic neurotransmitter receptor internalization and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including cellular response to electrical stimulus; inner ear development; and nervous system development. Located in several cellular components, including brush border; cochlear hair cell ribbon synapse; and glutamatergic synapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic actin cytoskeleton; and postsynaptic density. Is expressed in ear. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 13.1), placenta adult (RPKM 10.4) and 25 other tissues See more
Orthologs
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Genomic context

Location:
9 E1; 9 43.98 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (80072262..80219011)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (80164976..80311729)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24753 Neighboring gene STARR-seq mESC enhancer starr_24754 Neighboring gene STARR-positive B cell enhancer ABC_E715 Neighboring gene STARR-positive B cell enhancer ABC_E8303 Neighboring gene predicted gene, 46146 Neighboring gene SUMO/sentrin specific peptidase 6 Neighboring gene STARR-positive B cell enhancer ABC_E3848 Neighboring gene predicted gene 27227 Neighboring gene STARR-seq mESC enhancer starr_24757 Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene STARR-seq mESC enhancer starr_24758 Neighboring gene methyltransferase like 9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24759 Neighboring gene STARR-seq mESC enhancer starr_24760 Neighboring gene predicted gene, 39380

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to electrical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear auditory receptor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein targeting IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with clathrin-coated endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
is_active_in cochlear hair cell ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic actin cytoskeleton IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in presynaptic endocytic zone IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in vesicle membrane IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-VI
Names
Snell's waltzer
protein twist
tailchaser
unconventional myosin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039546.3NP_001034635.2  unconventional myosin-VI isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC120388, AC159738
    Consensus CDS
    CCDS23368.1
    UniProtKB/Swiss-Prot
    E9Q3L1, Q64331
    UniProtKB/TrEMBL
    B2RWR8
    Related
    ENSMUSP00000036181.9, ENSMUST00000035889.15
    Conserved Domains (3) summary
    smart00242
    Location:52771
    MYSc; Myosin. Large ATPases
    cd01382
    Location:71759
    MYSc_Myo6; class VI myosin, motor domain
    pfam16521
    Location:11451235
    Myosin-VI_CBD; Myosin VI cargo binding domain
  2. NM_001408252.1NP_001395181.1  unconventional myosin-VI isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC120388, AC159738
    UniProtKB/TrEMBL
    V9GX76
    Related
    ENSMUSP00000139019.2, ENSMUST00000184480.8
  3. NM_001408253.1NP_001395182.1  unconventional myosin-VI isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120388, AC159738
    Related
    ENSMUSP00000075501.4, ENSMUST00000076140.4
  4. NM_001408255.1NP_001395184.1  unconventional myosin-VI isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC120388, AC159738
    UniProtKB/TrEMBL
    E9Q175
    Related
    ENSMUSP00000108891.2, ENSMUST00000113266.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    80072262..80219011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510836.3XP_006510899.1  unconventional myosin-VI isoform X2

    UniProtKB/TrEMBL
    E9Q174, V9GXM4
    Conserved Domains (3) summary
    TIGR04211
    Location:845928
    SH3_and_anchor; SH3 domain protein
    cd01382
    Location:71759
    MYSc_Myo6; class VI myosin, motor domain
    pfam16521
    Location:11681258
    Myosin-VI_CBD; Myosin VI cargo binding domain
  2. XM_036154672.1XP_036010565.1  unconventional myosin-VI isoform X3

    UniProtKB/TrEMBL
    E9Q174
  3. XM_030244104.2XP_030099964.1  unconventional myosin-VI isoform X4

    UniProtKB/TrEMBL
    E9PVU0
    Conserved Domains (3) summary
    TIGR04211
    Location:845928
    SH3_and_anchor; SH3 domain protein
    cd01382
    Location:71759
    MYSc_Myo6; class VI myosin, motor domain
    pfam16521
    Location:11551245
    Myosin-VI_CBD; Myosin VI cargo binding domain

RNA

  1. XR_004935336.1 RNA Sequence

  2. XR_004935335.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008662.1: Suppressed sequence

    Description
    NM_008662.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.