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Myo1b myosin IB [ Mus musculus (house mouse) ]

Gene ID: 17912, updated on 29-Jan-2023

Summary

Official Symbol
Myo1bprovided by MGI
Official Full Name
myosin IBprovided by MGI
Primary source
MGI:MGI:107752
See related
Ensembl:ENSMUSG00000018417 AllianceGenome:MGI:107752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMIa; MIH-L
Summary
Predicted to enable several functions, including actin filament binding activity; anion binding activity; and calmodulin binding activity. Acts upstream of or within transferrin transport. Located in brush border. Is expressed in central nervous system and sensory organ. Orthologous to human MYO1B (myosin IB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 15.5), CNS E14 (RPKM 12.3) and 22 other tissues See more
Orthologs
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Genomic context

See Myo1b in Genome Data Viewer
Location:
1 C1.1; 1 26.58 cM
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (51788917..51955143, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (51749758..51916063, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17767 Neighboring gene predicted gene, 31636 Neighboring gene predicted gene, 33795 Neighboring gene predicted gene 8419 Neighboring gene ribosomal protein L15 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal motor activity ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament-based movement ISO
Inferred from Sequence Orthology
more info
 
involved_in post-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transferrin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Ib
Names
MMI-alpha
Myosin IA (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L)
molecular motor
myosin I alpha
myosin-Ib

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161817.2NP_001155289.1  unconventional myosin-Ib isoform 1

    See identical proteins and their annotated locations for NP_001155289.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC108840, BB768105, BC054786, BE950809, BY759345
    Consensus CDS
    CCDS48254.1
    UniProtKB/TrEMBL
    A0A8C6GB28, Q7TQD7
    Related
    ENSMUSP00000018561.8, ENSMUST00000018561.14
    Conserved Domains (3) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9411118
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. NM_001290982.1NP_001277911.1  unconventional myosin-Ib isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC108840, AK161062, BB768105, BC054786, BE950809, BY759345
    Consensus CDS
    CCDS69887.1
    UniProtKB/TrEMBL
    E9QNH6, Q3TTZ3, Q7TQD7
    Related
    ENSMUSP00000110184.3, ENSMUST00000114537.9
    Conserved Domains (4) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8831057
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  3. NM_010863.4NP_034993.2  unconventional myosin-Ib isoform 2

    See identical proteins and their annotated locations for NP_034993.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC108840, AK141207, BB768105, BC054786, BE950809, BY759345
    Consensus CDS
    CCDS14942.1
    UniProtKB/Swiss-Prot
    P46735, Q80VD8
    UniProtKB/TrEMBL
    Q7TQD7
    Related
    ENSMUSP00000040447.8, ENSMUST00000046390.14
    Conserved Domains (4) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    smart00242
    Location:16701
    MYSc; Myosin. Large ATPases
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9121086
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    51788917..51955143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495765.4XP_006495828.1  unconventional myosin-Ib isoform X1

    See identical proteins and their annotated locations for XP_006495828.1

    Conserved Domains (3) summary
    smart00015
    Location:751773
    IQ; Calmodulin-binding motif
    cd01378
    Location:29690
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9431120
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. XM_030252028.2XP_030107888.1  unconventional myosin-Ib isoform X2

    UniProtKB/TrEMBL
    A0A8C6GB28, Q7TQD7
    Conserved Domains (3) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9411118
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  3. XM_017319213.1XP_017174702.1  unconventional myosin-Ib isoform X7

    Conserved Domains (3) summary
    smart00015
    Location:628650
    IQ; Calmodulin-binding motif
    cl22853
    Location:1567
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:791968
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  4. XM_036162635.1XP_036018528.1  unconventional myosin-Ib isoform X6

    Conserved Domains (3) summary
    smart00015
    Location:628650
    IQ; Calmodulin-binding motif
    pfam06017
    Location:820997
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    cl22853
    Location:1567
    Motor_domain; Myosin and Kinesin motor domain
  5. XM_006495769.3XP_006495832.1  unconventional myosin-Ib isoform X5

    Conserved Domains (3) summary
    smart00015
    Location:630652
    IQ; Calmodulin-binding motif
    cl22853
    Location:1569
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:822999
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  6. XM_006495767.4XP_006495830.1  unconventional myosin-Ib isoform X4

    Conserved Domains (3) summary
    smart00015
    Location:751773
    IQ; Calmodulin-binding motif
    cd01378
    Location:29690
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8851062
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  7. XM_006495766.4XP_006495829.1  unconventional myosin-Ib isoform X3

    Conserved Domains (3) summary
    smart00015
    Location:751773
    IQ; Calmodulin-binding motif
    cd01378
    Location:29690
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9141091
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  8. XM_006495764.4XP_006495827.1  unconventional myosin-Ib isoform X1

    See identical proteins and their annotated locations for XP_006495827.1

    Conserved Domains (3) summary
    smart00015
    Location:751773
    IQ; Calmodulin-binding motif
    cd01378
    Location:29690
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9431120
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding