U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myl3 myosin, light polypeptide 3 [ Mus musculus (house mouse) ]

Gene ID: 17897, updated on 5-Mar-2024

Summary

Official Symbol
Myl3provided by MGI
Official Full Name
myosin, light polypeptide 3provided by MGI
Primary source
MGI:MGI:97268
See related
Ensembl:ENSMUSG00000059741 AllianceGenome:MGI:97268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mylc; VLC1; MLC1s; MLC1v; MLC1SB
Summary
Predicted to enable actin monomer binding activity and cytoskeletal motor activity. Predicted to be involved in several processes, including cardiac muscle contraction; regulation of the force of heart contraction; and ventricular cardiac muscle tissue morphogenesis. Predicted to be located in A band and I band. Predicted to be part of myosin complex. Is expressed in several structures, including diaphragm; eye; heart; limb segment; and skeletal musculature. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 3314.7) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Myl3 in Genome Data Viewer
Location:
9 F2; 9 60.69 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110592746..110598870)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110763678..110769802)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 12 Neighboring gene predicted gene, 35715 Neighboring gene parathyroid hormone 1 receptor Neighboring gene predicted gene, 35775 Neighboring gene predicted gene, 46141 Neighboring gene serine protease 42

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in A band ISO
Inferred from Sequence Orthology
more info
 
located_in I band ISO
Inferred from Sequence Orthology
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myosin light chain 3
Names
myosin light chain, alkali, cardiac ventricles
myosin, light polypeptide 3, alkali; ventricular, skeletal, slow

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364484.1NP_001351413.1  myosin light chain 3

    Status: VALIDATED

    Source sequence(s)
    AC139378
    Consensus CDS
    CCDS23571.1
    UniProtKB/Swiss-Prot
    P09542, Q3UIF4, Q9CQZ2
    UniProtKB/TrEMBL
    A0A0G2JDW2
    Related
    ENSMUSP00000142530.2, ENSMUST00000200011.5
    Conserved Domains (1) summary
    cl25352
    Location:53203
    EFh_PEF; The penta-EF hand (PEF) family
  2. NM_010859.3NP_034989.1  myosin light chain 3

    See identical proteins and their annotated locations for NP_034989.1

    Status: VALIDATED

    Source sequence(s)
    AK002312, AK146943, AV015350
    Consensus CDS
    CCDS23571.1
    UniProtKB/Swiss-Prot
    P09542, Q3UIF4, Q9CQZ2
    UniProtKB/TrEMBL
    A0A0G2JDW2
    Related
    ENSMUSP00000078715.8, ENSMUST00000079784.12
    Conserved Domains (1) summary
    cl25352
    Location:53203
    EFh_PEF; The penta-EF hand (PEF) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110592746..110598870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)