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Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha [ Mus musculus (house mouse) ]

Gene ID: 17888, updated on 2-Apr-2024

Summary

Official Symbol
Myh6provided by MGI
Official Full Name
myosin, heavy polypeptide 6, cardiac muscle, alphaprovided by MGI
Primary source
MGI:MGI:97255
See related
Ensembl:ENSMUSG00000040752 AllianceGenome:MGI:97255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myhca; Myhc-a; alphaMHC; alpha-MHC; A830009F23Rik
Summary
Enables microfilament motor activity. Involved in cardiac muscle contraction. Acts upstream of or within several processes, including adult heart development; muscle cell development; and regulation of heart contraction. Located in Z disc and stress fiber. Part of myosin complex. Is expressed in several structures, including brown fat; embryo mesenchyme; great vessel of heart; heart; and skeletal musculature. Used to study dilated cardiomyopathy; dilated cardiomyopathy 1EE; and hypertrophic cardiomyopathy 14. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 1317.1) See more
Orthologs
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Genomic context

See Myh6 in Genome Data Viewer
Location:
14 C3; 14 28.01 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55179378..55205553, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54941921..54968017, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene interleukin 25 Neighboring gene CKLF-like MARVEL transmembrane domain containing 5 Neighboring gene microRNA 208a Neighboring gene predicted gene, 52092 Neighboring gene myosin heavy chain associated RNA transcript Neighboring gene myosin, heavy polypeptide 7, cardiac muscle, beta Neighboring gene microRNA 208b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118706

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microfilament motor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin filament-based movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult heart development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adult heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle filament sliding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in muscle filament sliding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of ATP-dependent activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of heart growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visceral muscle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of muscle myosin complex ISO
Inferred from Sequence Orthology
more info
 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myosin-6
Names
alpha cardiac MHC
alpha myosin
cardiomyopathy, hypertrophic 1
myHC-alpha
myosin heavy chain 6
myosin heavy chain, cardiac muscle, adult

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164171.1NP_001157643.1  myosin-6

    See identical proteins and their annotated locations for NP_001157643.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    CT025533
    Consensus CDS
    CCDS36927.1
    UniProtKB/Swiss-Prot
    Q02566, Q64258, Q64738
    UniProtKB/TrEMBL
    B2RQQ1, Q2TAW4
    Related
    ENSMUSP00000080538.7, ENSMUST00000081857.14
    Conserved Domains (3) summary
    cd01377
    Location:99768
    MYSc_class_II; class II myosins, motor domain
    pfam01576
    Location:8481925
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3472
    Myosin_N; Myosin N-terminal SH3-like domain
  2. NM_010856.4NP_034986.1  myosin-6

    See identical proteins and their annotated locations for NP_034986.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    CT025533
    Consensus CDS
    CCDS36927.1
    UniProtKB/Swiss-Prot
    Q02566, Q64258, Q64738
    UniProtKB/TrEMBL
    B2RQQ1, Q2TAW4
    Related
    ENSMUSP00000154634.2, ENSMUST00000226297.2
    Conserved Domains (3) summary
    cd01377
    Location:99768
    MYSc_class_II; class II myosins, motor domain
    pfam01576
    Location:8481925
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3472
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55179378..55205553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518678.4XP_006518741.1  myosin-6 isoform X1

    See identical proteins and their annotated locations for XP_006518741.1

    UniProtKB/TrEMBL
    Q2TAW4
    Conserved Domains (3) summary
    cd01377
    Location:99768
    MYSc_class_II; class II myosins, motor domain
    pfam01576
    Location:8481925
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3472
    Myosin_N; Myosin N-terminal SH3-like domain
  2. XM_006518677.1XP_006518740.1  myosin-6 isoform X1

    See identical proteins and their annotated locations for XP_006518740.1

    UniProtKB/TrEMBL
    Q2TAW4
    Conserved Domains (3) summary
    cd01377
    Location:99768
    MYSc_class_II; class II myosins, motor domain
    pfam01576
    Location:8481925
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3472
    Myosin_N; Myosin N-terminal SH3-like domain
  3. XM_036158503.1XP_036014396.1  myosin-6 isoform X2

    UniProtKB/Swiss-Prot
    Q02566, Q64258, Q64738
    UniProtKB/TrEMBL
    B2RQQ1, Q2TAW4
    Conserved Domains (3) summary
    cd01377
    Location:99768
    MYSc_class_II; class II myosins, motor domain
    pfam01576
    Location:8481925
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3472
    Myosin_N; Myosin N-terminal SH3-like domain