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Myh3 myosin, heavy polypeptide 3, skeletal muscle, embryonic [ Mus musculus (house mouse) ]

Gene ID: 17883, updated on 2-Nov-2024

Summary

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Official Symbol
Myh3provided by MGI
Official Full Name
myosin, heavy polypeptide 3, skeletal muscle, embryonicprovided by MGI
Primary source
MGI:MGI:1339709
See related
Ensembl:ENSMUSG00000020908 AllianceGenome:MGI:1339709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myhse; Myhs-e; MyHC-emb
Summary
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. [provided by RefSeq, Sep 2015]
Expression
Biased expression in limb E14.5 (RPKM 52.1), CNS E14 (RPKM 5.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Myh3 in Genome Data Viewer
Location:
11 B3; 11 40.59 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66969101..66993117)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67078273..67102291)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29791 Neighboring gene transmembrane protein 220 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese dependent Neighboring gene STARR-seq mESC enhancer starr_29794 Neighboring gene SCO1 cytochrome c oxidase assembly protein Neighboring gene microRNA 6923 Neighboring gene RIKEN cDNA 2310065F04 gene Neighboring gene predicted gene, 31285

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Musculoskeletal defects associated with myosin heavy chain-embryonic loss of function are mediated by the YAP signaling pathway. Bharadwaj A, et al. EMBO Mol Med, 2023 Sep 11. PMID 37492882, Free PMC Article
  2. Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts. Isobe M, et al. PLoS One, 2018. PMID 30440034, Free PMC Article
  3. Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro. Robbins J, et al. J Biol Chem, 1990 Jul 15. PMID 1694848
  4. Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study. Sánchez A, et al. J Biol Chem, 1991 Nov 25. PMID 1939265
  5. The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle. Rigillo G, et al. Nat Commun, 2021 Oct 14. PMID 34650038, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Musculoskeletal defects associated with myosin heavy chain-embryonic loss of function are mediated by the YAP signaling pathway.
    Title: Musculoskeletal defects associated with myosin heavy chain-embryonic loss of function are mediated by the YAP signaling pathway.
  2. Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.
    Title: Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in contractile muscle fiber IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril IEA
Inferred from Electronic Annotation
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin-3
Names
myosin heavy chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099635.1 → NP_001093105.1  myosin-3

    See identical proteins and their annotated locations for NP_001093105.1

    Status: REVIEWED

    Source sequence(s)
    AL596129, AL645988
    Consensus CDS
    CCDS36184.1
    UniProtKB/Swiss-Prot
    P13541, Q3V183, Q5SUD4
    Conserved Domains (3) summary
    cd14913
    Location:100 → 767
    MYSc_Myh3; class II myosin heavy chain 3, motor domain
    pfam01576
    Location:847 → 1924
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:35 → 73
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    66969101..66993117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532412.2 → XP_006532475.1  myosin-3 isoform X1

    See identical proteins and their annotated locations for XP_006532475.1

    UniProtKB/Swiss-Prot
    P13541, Q3V183, Q5SUD4
    Related
    ENSMUSP00000104329.2, ENSMUST00000108689.8
    Conserved Domains (3) summary
    cd14913
    Location:100 → 767
    MYSc_Myh3; class II myosin heavy chain 3, motor domain
    pfam01576
    Location:847 → 1924
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:35 → 73
    Myosin_N; Myosin N-terminal SH3-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13541.2 GenPept UniProtKB/Swiss-Prot:P13541

Gene LinkOut

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