U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myh3 myosin, heavy polypeptide 3, skeletal muscle, embryonic [ Mus musculus (house mouse) ]

Gene ID: 17883, updated on 15-Nov-2022

Summary

Official Symbol
Myh3provided by MGI
Official Full Name
myosin, heavy polypeptide 3, skeletal muscle, embryonicprovided by MGI
Primary source
MGI:MGI:1339709
See related
Ensembl:ENSMUSG00000020908 AllianceGenome:MGI:1339709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myhse; Myhs-e; MyHC-emb
Summary
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. [provided by RefSeq, Sep 2015]
Expression
Biased expression in limb E14.5 (RPKM 52.1), CNS E14 (RPKM 5.2) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Myh3 in Genome Data Viewer
Location:
11 B3; 11 40.59 cM
Exon count:
41
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66969101..66993117)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67078273..67102291)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 220 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese dependent Neighboring gene SCO1 cytochrome c oxidase assembly protein Neighboring gene microRNA 6923 Neighboring gene RIKEN cDNA 2310065F04 gene Neighboring gene predicted gene, 31285

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myosin-3
Names
myosin heavy chain 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099635.1NP_001093105.1  myosin-3

    See identical proteins and their annotated locations for NP_001093105.1

    Status: REVIEWED

    Source sequence(s)
    AL596129, AL645988
    Consensus CDS
    CCDS36184.1
    UniProtKB/Swiss-Prot
    P13541, Q5SUD4
    Related
    ENSMUSP00000131883.2, ENSMUST00000165221.2
    Conserved Domains (3) summary
    cd14913
    Location:100767
    MYSc_Myh3; class II myosin heavy chain 3, motor domain
    pfam01576
    Location:8471924
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3573
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    66969101..66993117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532412.2XP_006532475.1  myosin-3 isoform X1

    See identical proteins and their annotated locations for XP_006532475.1

    UniProtKB/Swiss-Prot
    P13541, Q5SUD4
    Related
    ENSMUSP00000104329.2, ENSMUST00000108689.8
    Conserved Domains (3) summary
    cd14913
    Location:100767
    MYSc_Myh3; class II myosin heavy chain 3, motor domain
    pfam01576
    Location:8471924
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3573
    Myosin_N; Myosin N-terminal SH3-like domain