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Myf5 myogenic factor 5 [ Mus musculus (house mouse) ]

Gene ID: 17877, updated on 5-Mar-2024

Summary

Official Symbol
Myf5provided by MGI
Official Full Name
myogenic factor 5provided by MGI
Primary source
MGI:MGI:97252
See related
Ensembl:ENSMUSG00000000435 AllianceGenome:MGI:97252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myf-5; bHLHc2; B130010J22Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; regulation of cell-matrix adhesion; and somitogenesis. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and skeletal musculature. Orthologous to human MYF5 (myogenic factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 2.7), ovary adult (RPKM 0.6) and 1 other tissue See more
Orthologs
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Genomic context

See Myf5 in Genome Data Viewer
Location:
10 D1; 10 55.95 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (107318769..107322787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (107482908..107486927, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29674 Neighboring gene lin-7 homolog A, crumbs cell polarity complex component Neighboring gene STARR-seq mESC enhancer starr_27782 Neighboring gene STARR-seq mESC enhancer starr_27784 Neighboring gene myogenic factor 6 Neighboring gene STARR-seq mESC enhancer starr_27785 Neighboring gene protein tyrosine phosphatase receptor type Q

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within muscle organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle organ morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within muscle tissue morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of skeletal muscle fiber development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myogenic factor 5
Names
myogenic regulatory factor MYF-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008656.5NP_032682.1  myogenic factor 5

    See identical proteins and their annotated locations for NP_032682.1

    Status: VALIDATED

    Source sequence(s)
    AK044894, AK083402
    Consensus CDS
    CCDS24161.1
    UniProtKB/Swiss-Prot
    P24699, Q543W7
    UniProtKB/TrEMBL
    A2RSK4
    Related
    ENSMUSP00000000445.2, ENSMUST00000000445.2
    Conserved Domains (3) summary
    smart00520
    Location:188
    BASIC; Basic domain in HLH proteins of MYOD family
    pfam12232
    Location:143214
    Myf5; Myogenic determination factor 5
    cd18937
    Location:83146
    bHLH_TS_Myf5; basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    107318769..107322787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513319.3XP_006513382.1  myogenic factor 5 isoform X1

    See identical proteins and their annotated locations for XP_006513382.1

    UniProtKB/Swiss-Prot
    P24699, Q543W7
    UniProtKB/TrEMBL
    A2RSK4
    Conserved Domains (3) summary
    smart00520
    Location:188
    BASIC; Basic domain in HLH proteins of MYOD family
    pfam12232
    Location:143214
    Myf5; Myogenic determination factor 5
    cd18937
    Location:83146
    bHLH_TS_Myf5; basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins