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Mup1 major urinary protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17840, updated on 8-Feb-2024

Summary

Official Symbol
Mup1provided by MGI
Official Full Name
major urinary protein 1provided by MGI
Primary source
MGI:MGI:97233
See related
Ensembl:ENSMUSG00000078683 AllianceGenome:MGI:97233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mup7; Up-1; Ltn-1; Mup-1; Mup-a; Mup10; Lvtn-1
Summary
Enables insulin-activated receptor activity; pheromone activity; and pheromone binding activity. Involved in several processes, including locomotor rhythm; mitochondrion morphogenesis; and negative regulation of biosynthetic process. Acts upstream of or within several processes, including cellular response to food; cellular response to testosterone stimulus; and response to stilbenoid. Located in cytosol; extracellular space; and nucleus. Is expressed in several structures, including branchial arch; forelimb bud; genital tubercle; hemolymphoid system; and limb. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 1970.0) See more
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Genomic context

See Mup1 in Genome Data Viewer
Location:
4 B3; 4 32.85 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (60454011..60457959, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (60498012..60501960, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene major urinary protein, pseudogene 4 Neighboring gene major urinary protein, pseudogene 26 Neighboring gene major urinary protein, pseudogene 6 Neighboring gene major urinary protein, pseudogene 24

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables insulin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pheromone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pheromone binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to food IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to testosterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in energy reserve metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heat generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in locomotor rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lipid storage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
major urinary protein 1
Names
MUP 1
major urinary protein 10
major urinary protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163010.1NP_001156482.1  major urinary protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001156482.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    CR589880
    Consensus CDS
    CCDS18231.1
    UniProtKB/Swiss-Prot
    P11589, Q99JF6
    UniProtKB/TrEMBL
    A2CEL1, B5TE76, B5X0G0
    Related
    ENSMUSP00000103123.4, ENSMUST00000107499.4
    Conserved Domains (1) summary
    pfam00061
    Location:34170
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_001163011.1NP_001156483.1  major urinary protein 1 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    CR589880
    Consensus CDS
    CCDS51188.1
    UniProtKB/TrEMBL
    A2CEL0
    Related
    ENSMUSP00000081596.5, ENSMUST00000084548.11
    Conserved Domains (1) summary
    pfam00061
    Location:34170
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  3. NM_031188.2NP_112465.2  major urinary protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_112465.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    CR589880
    Consensus CDS
    CCDS18231.1
    UniProtKB/Swiss-Prot
    P11589, Q99JF6
    UniProtKB/TrEMBL
    A2CEL1, B5TE76, B5X0G0
    Related
    ENSMUSP00000100077.4, ENSMUST00000103012.10
    Conserved Domains (1) summary
    pfam00061
    Location:34170
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    60454011..60457959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)