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Mttp microsomal triglyceride transfer protein [ Mus musculus (house mouse) ]

Gene ID: 17777, updated on 5-Mar-2019

Summary

Official Symbol
Mttpprovided by MGI
Official Full Name
microsomal triglyceride transfer proteinprovided by MGI
Primary source
MGI:MGI:106926
See related
Ensembl:ENSMUSG00000028158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTP; 1810043K16Rik
Expression
Biased expression in large intestine adult (RPKM 62.5), duodenum adult (RPKM 33.4) and 6 other tissues See more
Orthologs

Genomic context

See Mttp in Genome Data Viewer
Location:
3 G3; 3 64.06 cM
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (138089855..138143461, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (137752819..137806352, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Neighboring gene predicted gene, 19708 Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene predicted gene 5105 Neighboring gene RIKEN cDNA 4930579F01 gene Neighboring gene tRNA methyltransferase 10A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
phospholipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid transport ISO
Inferred from Sequence Orthology
more info
 
lipoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
lipoprotein transport IDA
Inferred from Direct Assay
more info
PubMed 
lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
plasma lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
protein lipidation IDA
Inferred from Direct Assay
more info
PubMed 
protein secretion ISO
Inferred from Sequence Orthology
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
microsomal triglyceride transfer protein large subunit
Names
microsomal triglyceride transfer protein B
microsomal triglyceride transfer protein, large subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163457.2NP_001156929.1  microsomal triglyceride transfer protein large subunit isoform 1 precursor

    See identical proteins and their annotated locations for NP_001156929.1

    Status: VALIDATED

    Source sequence(s)
    AC131122, AK136278, AK146553
    Consensus CDS
    CCDS51080.1
    UniProtKB/Swiss-Prot
    O08601
    Related
    ENSMUSP00000096179.2, ENSMUST00000098580.5
    Conserved Domains (1) summary
    pfam01347
    Location:43594
    Vitellogenin_N; Lipoprotein amino terminal region
  2. NM_001355051.1NP_001341980.1  microsomal triglyceride transfer protein large subunit isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131122
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region
  3. NM_001355052.1NP_001341981.1  microsomal triglyceride transfer protein large subunit isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131122
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region
  4. NM_008642.3NP_032668.2  microsomal triglyceride transfer protein large subunit isoform 2 precursor

    See identical proteins and their annotated locations for NP_032668.2

    Status: VALIDATED

    Source sequence(s)
    AC131122, AK146553
    Consensus CDS
    CCDS38650.1
    UniProtKB/Swiss-Prot
    O08601
    Related
    ENSMUSP00000029805.8, ENSMUST00000029805.12
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    138089855..138143461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501103.3XP_006501166.1  microsomal triglyceride transfer protein large subunit isoform X2

    See identical proteins and their annotated locations for XP_006501166.1

    UniProtKB/Swiss-Prot
    O08601
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region
  2. XM_006501102.3XP_006501165.1  microsomal triglyceride transfer protein large subunit isoform X1

    See identical proteins and their annotated locations for XP_006501165.1

    UniProtKB/Swiss-Prot
    O08601
    Conserved Domains (1) summary
    pfam01347
    Location:43594
    Vitellogenin_N; Lipoprotein amino terminal region
  3. XM_017319474.1XP_017174963.1  microsomal triglyceride transfer protein large subunit isoform X2

    UniProtKB/Swiss-Prot
    O08601
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region
  4. XM_017319475.1XP_017174964.1  microsomal triglyceride transfer protein large subunit isoform X2

    UniProtKB/Swiss-Prot
    O08601
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region
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