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Mttp microsomal triglyceride transfer protein [ Mus musculus (house mouse) ]

Gene ID: 17777, updated on 24-Jan-2023

Summary

Official Symbol
Mttpprovided by MGI
Official Full Name
microsomal triglyceride transfer proteinprovided by MGI
Primary source
MGI:MGI:106926
See related
Ensembl:ENSMUSG00000028158 AllianceGenome:MGI:106926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTP; 1810043K16Rik
Summary
Enables cholesterol transfer activity; phosphatidylethanolamine transfer activity; and triglyceride transfer activity. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein transport; and low-density lipoprotein particle remodeling. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in gut; liver; placenta; septum transversum hepatic component; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 62.5), duodenum adult (RPKM 33.4) and 6 other tissues See more
Orthologs
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Genomic context

See Mttp in Genome Data Viewer
Location:
3 G3; 3 64.06 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137795616..137849179, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138089855..138143418, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene predicted gene 5105 Neighboring gene predicted gene, 52617 Neighboring gene tRNA methyltransferase 10A Neighboring gene RIKEN cDNA 4930579F01 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables ceramide 1-phosphate transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylethanolamine transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylethanolamine transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables triglyceride transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables triglyceride transfer activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lipoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein lipidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within triglyceride metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
microsomal triglyceride transfer protein large subunit
Names
microsomal triglyceride transfer protein B
microsomal triglyceride transfer protein, large subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163457.2NP_001156929.1  microsomal triglyceride transfer protein large subunit isoform 1 precursor

    See identical proteins and their annotated locations for NP_001156929.1

    Status: VALIDATED

    Source sequence(s)
    AC131122, AK136278, AK146553
    Consensus CDS
    CCDS51080.1
    UniProtKB/Swiss-Prot
    O08601
    Related
    ENSMUSP00000096179.3, ENSMUST00000098580.6
    Conserved Domains (1) summary
    cl26969
    Location:43594
    Vitellogenin_N; Lipoprotein amino terminal region
  2. NM_001355051.1NP_001341980.1  microsomal triglyceride transfer protein large subunit isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131122
    Consensus CDS
    CCDS38650.1
    UniProtKB/Swiss-Prot
    Q91X33
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region
  3. NM_001355052.1NP_001341981.1  microsomal triglyceride transfer protein large subunit isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131122
    Consensus CDS
    CCDS38650.1
    UniProtKB/Swiss-Prot
    Q91X33
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region
  4. NM_008642.3NP_032668.2  microsomal triglyceride transfer protein large subunit isoform 2 precursor

    See identical proteins and their annotated locations for NP_032668.2

    Status: VALIDATED

    Source sequence(s)
    AC131122, AK146553
    Consensus CDS
    CCDS38650.1
    UniProtKB/Swiss-Prot
    O08601, Q91X33
    Related
    ENSMUSP00000029805.9, ENSMUST00000029805.13
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    137795616..137849179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501102.4XP_006501165.1  microsomal triglyceride transfer protein large subunit isoform X1

    See identical proteins and their annotated locations for XP_006501165.1

    UniProtKB/Swiss-Prot
    O08601
    Conserved Domains (1) summary
    cl26969
    Location:43594
    Vitellogenin_N; Lipoprotein amino terminal region
  2. XM_006501103.4XP_006501166.1  microsomal triglyceride transfer protein large subunit isoform X2

    See identical proteins and their annotated locations for XP_006501166.1

    UniProtKB/Swiss-Prot
    O08601, Q91X33
    Conserved Domains (1) summary
    cl26969
    Location:28579
    Vitellogenin_N; Lipoprotein amino terminal region