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Mtnr1a melatonin receptor 1A [ Mus musculus (house mouse) ]

Gene ID: 17773, updated on 20-Dec-2022

Summary

Official Symbol
Mtnr1aprovided by MGI
Official Full Name
melatonin receptor 1Aprovided by MGI
Primary source
MGI:MGI:102967
See related
Ensembl:ENSMUSG00000054764 AllianceGenome:MGI:102967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MR; MelR
Summary
Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of insulin secretion. Predicted to act upstream of or within signal transduction. Predicted to be located in neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; gonad; intestine; and liver and biliary system. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.3), liver adult (RPKM 0.1) and 3 other tissues See more
Orthologs
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Genomic context

See Mtnr1a in Genome Data Viewer
Location:
8 B1.1; 8 24.95 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (45522144..45542270)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45069107..45089233)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 1 Neighboring gene cDNA sequence AY512931 Neighboring gene predicted gene, 30504 Neighboring gene predicted gene 6329 Neighboring gene coagulation factor XI

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC151277

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables melatonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables melatonin receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
melatonin receptor type 1A
Names
Mel1a receptor
mel-1A-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008639.3NP_032665.1  melatonin receptor type 1A

    See identical proteins and their annotated locations for NP_032665.1

    Status: VALIDATED

    Source sequence(s)
    AC158352
    Consensus CDS
    CCDS22273.1
    UniProtKB/Swiss-Prot
    Q61184
    UniProtKB/TrEMBL
    Q14AC3
    Related
    ENSMUSP00000069872.8, ENSMUST00000067984.9
    Conserved Domains (2) summary
    pfam00001
    Location:47298
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:38160
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    45522144..45542270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509292.2XP_006509355.2  melatonin receptor type 1A isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:3156
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:27275
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_017312597.1XP_017168086.1  melatonin receptor type 1A isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:3055
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:26274
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_011242176.1XP_011240478.1  melatonin receptor type 1A isoform X4

    Conserved Domains (2) summary
    cd14964
    Location:328
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:3247
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_006509291.3XP_006509354.1  melatonin receptor type 1A isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:328
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:3247
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily