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Nudt1 nudix hydrolase 1 [ Mus musculus (house mouse) ]

Gene ID: 17766, updated on 5-Mar-2024

Summary

Official Symbol
Nudt1provided by MGI
Official Full Name
nudix hydrolase 1provided by MGI
Primary source
MGI:MGI:109280
See related
Ensembl:ENSMUSG00000036639 AllianceGenome:MGI:109280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mth1
Summary
Enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity and snoRNA binding activity. Predicted to be involved in DNA protection and purine nucleoside catabolic process. Predicted to be located in several cellular components, including acrosomal vesicle; mitochondrial matrix; and nuclear membrane. Predicted to be active in cytoplasm. Orthologous to human NUDT1 (nudix hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.3), liver E14 (RPKM 9.0) and 28 other tissues See more
Orthologs
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Genomic context

See Nudt1 in Genome Data Viewer
Location:
5 G2; 5 78.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140307375..140323892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140321622..140338137)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and fibronectin type III, extracellular 1 Neighboring gene MAD1 mitotic arrest deficient 1-like 1 Neighboring gene predicted gene, 30492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140619500-140619609 Neighboring gene STARR-seq mESC enhancer starr_14706 Neighboring gene STARR-seq mESC enhancer starr_14707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140684659-140684995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140686457-140686707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140691391-140691751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140736675-140736858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140740159-140740368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140747294-140747554 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140758495-140758709 Neighboring gene STARR-positive B cell enhancer ABC_E6391 Neighboring gene STARR-seq mESC enhancer starr_14708 Neighboring gene STARR-positive B cell enhancer ABC_E9018 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E9267 Neighboring gene sorting nexin 8 Neighboring gene predicted gene, 30550

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA protection IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA protection ISO
Inferred from Sequence Orthology
more info
 
involved_in purine nucleoside catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
oxidized purine nucleoside triphosphate hydrolase
Names
2-hydroxy-dATP diphosphatase
7,8-dihydro-8-oxoguanine triphosphatase
8-oxo-7,8-dihydro-2'-dGTPase
8-oxo-dGTPase
methylated purine nucleoside triphosphate hydrolase
mutT human homolog (8-oxo-dGTPase)
nucleoside diphosphate-linked moiety X motif 1
nudix (nucleoside diphosphate linked moiety X)-type motif 1
nudix motif 1
NP_001343512.1
NP_001343513.1
NP_001343514.1
NP_001407087.1
NP_032663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356583.2NP_001343512.1  oxidized purine nucleoside triphosphate hydrolase

    Status: VALIDATED

    Source sequence(s)
    AC131670
    Consensus CDS
    CCDS19818.1
    UniProtKB/Swiss-Prot
    P53368, P97795, Q542J4, Q8VDG0
    Related
    ENSMUSP00000071778.4, ENSMUST00000071881.10
    Conserved Domains (1) summary
    cd03427
    Location:6140
    MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
  2. NM_001356584.2NP_001343513.1  oxidized purine nucleoside triphosphate hydrolase

    Status: VALIDATED

    Source sequence(s)
    AC131670
    Consensus CDS
    CCDS19818.1
    UniProtKB/Swiss-Prot
    P53368, P97795, Q542J4, Q8VDG0
    Related
    ENSMUSP00000106451.2, ENSMUST00000110827.8
    Conserved Domains (1) summary
    cd03427
    Location:6140
    MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
  3. NM_001356585.2NP_001343514.1  oxidized purine nucleoside triphosphate hydrolase

    Status: VALIDATED

    Source sequence(s)
    AC131670
    Consensus CDS
    CCDS19818.1
    UniProtKB/Swiss-Prot
    P53368, P97795, Q542J4, Q8VDG0
    Conserved Domains (1) summary
    cd03427
    Location:6140
    MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
  4. NM_001420158.1NP_001407087.1  oxidized purine nucleoside triphosphate hydrolase

    Status: VALIDATED

    Source sequence(s)
    AC131670
    UniProtKB/Swiss-Prot
    P53368, P97795, Q542J4, Q8VDG0
  5. NM_008637.3NP_032663.1  oxidized purine nucleoside triphosphate hydrolase

    See identical proteins and their annotated locations for NP_032663.1

    Status: VALIDATED

    Source sequence(s)
    AC131670
    Consensus CDS
    CCDS19818.1
    UniProtKB/Swiss-Prot
    P53368, P97795, Q542J4, Q8VDG0
    Related
    ENSMUSP00000059983.6, ENSMUST00000050205.12
    Conserved Domains (1) summary
    cd03427
    Location:6140
    MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    140307375..140323892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)