Nudt1 nudix hydrolase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt1provided by MGI
Official Full Name: nudix hydrolase 1provided by MGI
Primary source: MGI:MGI:109280
See related: Ensembl:ENSMUSG00000036639 AllianceGenome:MGI:109280
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mth1
Summary: Enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity and snoRNA binding activity. Predicted to be involved in DNA protection and purine nucleoside catabolic process. Predicted to be located in several cellular components, including acrosomal vesicle; mitochondrial matrix; and nuclear membrane. Predicted to be active in cytoplasm. Orthologous to human NUDT1 (nudix hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 12.3), liver E14 (RPKM 9.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 G2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (140307377..140323892)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (140321622..140338137)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NUDT1 promotes the accumulation and longevity of CD103(+) TRM cells in primary biliary cholangitis.
Title: NUDT1 promotes the accumulation and longevity of CD103(+) T(RM) cells in primary biliary cholangitis.
Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases.
Title: Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases.
MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.
Title: MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.
MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage.
Title: MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage.
Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1.
Title: Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1.
Role of As3mt and Mth1 in the genotoxic and carcinogenic effects induced by long-term exposures to arsenic in MEF cells.
Title: Role of As3mt and Mth1 in the genotoxic and carcinogenic effects induced by long-term exposures to arsenic in MEF cells.
Increased cytotoxicity following MTH1 knockout or treatment with MTH1 inhibitor suggests the oxidation of precursor nucleotides.
Title: Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.
The crystal structures of mouse MTH1 in complex with inhibitor TH588 and dog MTH1 elucidate the structural and sequence basis for the observed difference in their affinities for TH588. Amino acid residue 116 in MTH1 is an important determinant of TH588 affinity. The structure of mouse MTH1 in complex with the substrate 8-oxo-dGTP is presented.
Title: Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.
Title: Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients.
An age-related higher level of 8-oxodG even occurs concomitantly with high 8-oxodGTPase activity.
Title: Aging and defense against generation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Homology

Homologs of the Nudt1 gene: The Nudt1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 490 organisms have orthologs with human gene Nudt1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-hydroxy-ATP hydrolase activity	ISO Inferred from Sequence Orthology more info
enables 2-hydroxy-dATP hydrolase activity	ISO Inferred from Sequence Orthology more info
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables ATP diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables dATP diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables snoRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA protection	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in DNA protection	ISO Inferred from Sequence Orthology more info
involved_in purine nucleoside catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: oxidized purine nucleoside triphosphate hydrolase; 7,8-dihydro-8-oxoguanine triphosphatase

Names: 2-hydroxy-dATP diphosphatase; 8-oxo-7,8-dihydro-2'-dGTPase; 8-oxo-dGTPase; methylated purine nucleoside triphosphate hydrolase; mutT human homolog (8-oxo-dGTPase); nucleoside diphosphate-linked moiety X motif 1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; nudix motif 1

NP_001343512.1

EC 3.6.1.56

NP_001343513.1

EC 3.6.1.56

NP_001343514.1

EC 3.6.1.56

NP_032663.1

EC 3.6.1.56

XP_006504718.1

EC 3.6.1.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356583.1 → NP_001343512.1 oxidized purine nucleoside triphosphate hydrolase

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

BC098239, DV649386

Consensus CDS

CCDS19818.1

UniProtKB/Swiss-Prot

Q8VDG0

Related

ENSMUSP00000071778.4, ENSMUST00000071881.10

Conserved Domains (1) summary

cd03427
Location:6 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
NM_001356584.1 → NP_001343513.1 oxidized purine nucleoside triphosphate hydrolase

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC131670

Consensus CDS

CCDS19818.1

UniProtKB/Swiss-Prot

Q8VDG0

Related

ENSMUSP00000106451.2, ENSMUST00000110827.8

Conserved Domains (1) summary

cd03427
Location:6 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
NM_001356585.1 → NP_001343514.1 oxidized purine nucleoside triphosphate hydrolase

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC131670

Consensus CDS

CCDS19818.1

UniProtKB/Swiss-Prot

Q8VDG0

Conserved Domains (1) summary

cd03427
Location:6 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
NM_008637.2 → NP_032663.1 oxidized purine nucleoside triphosphate hydrolase

See identical proteins and their annotated locations for NP_032663.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript. All four variants encode the same protein.

Source sequence(s)

BC098239, BQ560459, DV649386

Consensus CDS

CCDS19818.1

UniProtKB/Swiss-Prot

P53368, Q8VDG0

Related

ENSMUSP00000059983.6, ENSMUST00000050205.12

Conserved Domains (1) summary

cd03427
Location:6 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

140307377..140323892

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504655.4 → XP_006504718.1 7,8-dihydro-8-oxoguanine triphosphatase isoform X1

See identical proteins and their annotated locations for XP_006504718.1

UniProtKB/Swiss-Prot

P53368, Q8VDG0

Related

ENSMUSP00000106450.2, ENSMUST00000110826.8

Conserved Domains (1) summary

cd03427
Location:6 → 140

MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...