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DNASE1L2 deoxyribonuclease 1 like 2 [ Homo sapiens (human) ]

Gene ID: 1775, updated on 17-Nov-2020

Summary

Official Symbol
DNASE1L2provided by HGNC
Official Full Name
deoxyribonuclease 1 like 2provided by HGNC
Primary source
HGNC:HGNC:2958
See related
Ensembl:ENSG00000167968 MIM:602622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNAS1L2
Expression
Broad expression in skin (RPKM 3.2), brain (RPKM 0.6) and 14 other tissues See more
Orthologs

Genomic context

See DNASE1L2 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2236444..2238711)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2286253..2288712)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5944 Neighboring gene E4F transcription factor 1 Neighboring gene enoyl-CoA delta isomerase 1 Neighboring gene uncharacterized LOC107984839 Neighboring gene RNA binding protein with serine rich domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
deoxyribonuclease I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA catabolic process, endonucleolytic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA metabolic process TAS
Traceable Author Statement
more info
PubMed 
corneocyte development IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
deoxyribonuclease-1-like 2
Names
DNase I homolog protein DHP1
DNase I-like 2
deoxyribonuclease I like 2
NP_001288609.1
NP_001365.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301680.2NP_001288609.1  deoxyribonuclease-1-like 2 precursor

    See identical proteins and their annotated locations for NP_001288609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009065, BC035205, BC063710
    Consensus CDS
    CCDS42105.1
    UniProtKB/Swiss-Prot
    Q92874
    Related
    ENSP00000455358.1, ENST00000567494.5
    Conserved Domains (1) summary
    smart00476
    Location:18296
    DNaseIc; deoxyribonuclease I
  2. NM_001374.3NP_001365.1  deoxyribonuclease-1-like 2 precursor

    See identical proteins and their annotated locations for NP_001365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009065, BC063710
    Consensus CDS
    CCDS42105.1
    UniProtKB/Swiss-Prot
    Q92874
    Related
    ENSP00000316938.5, ENST00000320700.10
    Conserved Domains (1) summary
    smart00476
    Location:18296
    DNaseIc; deoxyribonuclease I

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2236444..2238711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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