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mt-Nd6 NADH dehydrogenase 6, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17722, updated on 14-May-2024

Summary

Official Symbol
mt-Nd6provided by MGI
Official Full Name
NADH dehydrogenase 6, mitochondrialprovided by MGI
Primary source
MGI:MGI:102495
See related
AllianceGenome:MGI:102495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ND6
Summary
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in brain; early conceptus; and secondary oocyte. Used to study Leber hereditary optic neuropathy and lactic acidosis. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and spinal muscular atrophy with lower extremity predominante 2B. Orthologous to human MT-ND6 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (13552..14070, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (13552..14070, complement)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene tRNA-Ser Neighboring gene tRNA-Leu Neighboring gene NADH dehydrogenase subunit 5 Neighboring gene tRNA-Glu Neighboring gene cytochrome b

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically and radiation induced (1)  1 citation
  • Endonuclease-mediated (1) 
  • Spontaneous (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

  • URF6

General protein information

Names
NADH dehydrogenase subunit 6
NP_904339.1
  • EST AA435281

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    13552..14070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904339.1 NADH dehydrogenase subunit 6 (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03925
    UniProtKB/TrEMBL
    A0A067XKX2, A0A0F6PYW9, A9UIY5, B9V1E5, K7XKA1, Q7JCY4, Q7JCZ7
    Related
    ENSMUSP00000081002.1
    Conserved Domains (1) summary
    MTH00109
    Location:1171
    ND6; NADH dehydrogenase subunit 6; Provisional