U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mt-Nd2 NADH dehydrogenase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17717, updated on 8-Feb-2024

Summary

Official Symbol
mt-Nd2provided by MGI
Official Full Name
NADH dehydrogenase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:102500
See related
AllianceGenome:MGI:102500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ND2
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity; ionotropic glutamate receptor binding activity; and protein kinase binding activity. Acts upstream of or within reactive oxygen species metabolic process. Located in mitochondrion. Is expressed in early conceptus and secondary oocyte. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; multiple sclerosis; myocardial infarction; neurodegenerative disease (multiple); and urinary bladder cancer. Orthologous to human MT-ND2 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (3914..4951)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (3914..4951)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene tRNA-Gln Neighboring gene tRNA-Met Neighboring gene tRNA-Trp Neighboring gene tRNA-Ala Neighboring gene tRNA-Asn

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

  • URF2

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Names
NADH dehydrogenase subunit 2
NP_904329.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    3914..4951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904329.1 NADH dehydrogenase subunit 2 (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904329.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03893
    UniProtKB/TrEMBL
    A0A067XKM8, A0A067XKW9, A0A6M8TW30, A3R414, M1VMU3, Q6QN84, Q7JD05, Q9MD59
    Related
    ENSMUSP00000080992.1
    Conserved Domains (1) summary
    MTH00105
    Location:1345
    ND2; NADH dehydrogenase subunit 2; Provisional