U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mt-Cytb cytochrome b, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17711, updated on 11-Apr-2024

Summary

Official Symbol
mt-Cytbprovided by MGI
Official Full Name
cytochrome b, mitochondrialprovided by MGI
Primary source
MGI:MGI:102501
See related
AllianceGenome:MGI:102501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus (strain: C57BL/6J)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CYTB
Summary
Predicted to enable metal ion binding activity and ubiquinol-cytochrome-c reductase activity. Predicted to be involved in several processes, including electron transport coupled proton transport; mitochondrial electron transport, ubiquinol to cytochrome c; and response to glucagon. Located in membrane and mitochondrion. Is integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (14145..15288)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (14145..15288)

Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 5 Neighboring gene NADH dehydrogenase subunit 6 Neighboring gene tRNA-Glu Neighboring gene tRNA-Thr Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquinol-cytochrome-c reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cellular respiration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in electron transport coupled proton transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
Non-traceable Author Statement
more info
PubMed 
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucagon ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mercury ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 
part_of respiratory chain complex III IEA
Inferred from Electronic Annotation
more info
 

General protein information

Names
cytochrome b
NP_904340.1
  • TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005089.1 Reference assembly

    Range
    14145..15288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_904340.1 cytochrome b (mitochondrion) [Mus musculus]

    See identical proteins and their annotated locations for NP_904340.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00158
    UniProtKB/TrEMBL
    A0A0F6PXN8, A0A0F6PYR5, A0A0F6PZ78, A0A650FQN5, A3R3Q8, B1P8W3, G3EBA2, Q401X6, Q5WA15, Q7JCZ3, Q7JCZ6, Q9TEY3
    Related
    ENSMUSP00000081003.1
    Conserved Domains (1) summary
    MTH00100
    Location:1378
    CYTB; cytochrome b; Provisional