mt-Co1 cytochrome c oxidase I, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Co1provided by MGI
Official Full Name: cytochrome c oxidase I, mitochondrialprovided by MGI
Primary source: MGI:MGI:102504
See related: AllianceGenome:MGI:102504
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CoxI; COX1
Summary: Enables cytochrome-c oxidase activity. Predicted to be involved in aerobic respiration; respiratory electron transport chain; and response to oxidative stress. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Is active in mitochondrion. Is expressed in several structures, including brain; brown fat; liver; musculature; and stomach. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (5328..6872)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (5328..6872)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Defective COX1 expression in aging mice liver.
Title: Defective COX1 expression in aging mice liver.
Low aortic mitochondria-encoded COX1 in obese diabetic double knock-out mice was associated with a larger plaque area and higher M1 macrophages and oxidized LDL. Caloric restriction increased COX1 and reduced plaque area and oxidized LDL. Low COX1 related to low expression of PPAR alpha, delta, and gamma and of peroxisome proliferative activated receptor, gamma, co-activator 1 alpha reflecting mitochondrial dysfunction.
Title: Low Cytochrome Oxidase 1 Links Mitochondrial Dysfunction to Atherosclerosis in Mice and Pigs.
a dependence of COX1 AND capital ES, CyrillicOX2 expression on the presence of MMP-9 was shown in neutrophil infiltration during inflammation.
Title: Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.
IOP elevation may directly damage mitochondria in the ONH axons by promoting reduction of COX, mitochondrial fission and cristae depletion, alterations of OPA1 and Dnm1 expression, and induction of OPA1 release.
Title: Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve.
Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase
Title: Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase.
CcOX I protein levels significantly decreased following CO exposure while enzyme turnover number and CcOX I mRNA levels remained unchanged.
Title: Myocardial cytochrome oxidase activity is decreased following carbon monoxide exposure.
The gene expression of Cox1 in adipocytes was studied.
Title: Gene expression of isoformic enzymes in arachidonate cyclooxygenase pathway and the regulation by tumor necrosis factor alpha during life cycle of adipocytes.
CCOI expression is inhibited by osteopontin as the result of a novel CD44-dependent transcriptional regulatory mechanism of the mitochondrial H strand
Title: Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fk25g03.x1 (e-PCR)
- UniSTS:200706

RH136461 (e-PCR)
- UniSTS:210447

RH136213 (e-PCR)
- UniSTS:210208

RH136219 (e-PCR)
- UniSTS:210213

RH136241 (e-PCR)
- UniSTS:210235

mt-Nd2 (e-PCR), detects polymorphism
- UniSTS:496722

NoName (e-PCR)
- UniSTS:234086

NoName (e-PCR)
- UniSTS:234087

NoName (e-PCR)
- UniSTS:234088

RH136305 (e-PCR)
- UniSTS:210297

RH136337 (e-PCR)
- UniSTS:210327

RH136347 (e-PCR)
- UniSTS:210337

PMC307645P1 (e-PCR)
- UniSTS:272585

RH136413 (e-PCR)
- UniSTS:210403

RH136419 (e-PCR)
- UniSTS:210409

Homology

Orthologs from OrthoDB

COI; CCOI

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytochrome-c oxidase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info
contributes_to cytochrome-c oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in respiratory electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to copper ion	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex III	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	ISS Inferred from Sequence or Structural Similarity more info