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Irag1 inositol 1,4,5-triphosphate receptor associated 1 [ Mus musculus (house mouse) ]

Gene ID: 17540, updated on 24-Jan-2023

Summary

Official Symbol
Irag1provided by MGI
Official Full Name
inositol 1,4,5-triphosphate receptor associated 1provided by MGI
Primary source
MGI:MGI:1338023
See related
Ensembl:ENSMUSG00000005611 AllianceGenome:MGI:1338023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irag; Ris1; Mrvi1
Summary
This gene is a putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein participates in signaling by nitric oxide (NO) to inhibit intracellular calcium release and platelet aggregation in cardiovascular tissue. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
Expression
Biased expression in bladder adult (RPKM 34.2), subcutaneous fat pad adult (RPKM 20.8) and 13 other tissues See more
Orthologs
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Genomic context

See Irag1 in Genome Data Viewer
Location:
7 E3; 7 57.9 cM
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110467464..110582116, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110868257..110982909, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene ring finger protein 141 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene predicted gene 16336 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene eukaryotic translation initiation factor 4, gamma 2 Neighboring gene predicted gene, 23262

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inositol 1,4,5-triphosphate receptor associated 1
Names
JAW1-related protein MRVI1
MRV integration site 1
inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
murine retrovirus integration site 1 protein
protein MRVI1
retroviral integration site 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194464.3NP_919446.2  inositol 1,4,5-triphosphate receptor associated 1

    See identical proteins and their annotated locations for NP_919446.2

    Status: REVIEWED

    Source sequence(s)
    AC159206, AC184052, AK020536, AK141821
    Consensus CDS
    CCDS21749.1
    UniProtKB/TrEMBL
    Q3UR44
    Related
    ENSMUSP00000005751.7, ENSMUST00000005751.13
    Conserved Domains (1) summary
    pfam05781
    Location:272856
    MRVI1; MRVI1 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    110467464..110582116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507416.3XP_006507479.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

    See identical proteins and their annotated locations for XP_006507479.1

    UniProtKB/Swiss-Prot
    Q9WUX5
    Conserved Domains (1) summary
    pfam05781
    Location:272856
    MRVI1; MRVI1 protein
  2. XM_006507415.4XP_006507478.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

    See identical proteins and their annotated locations for XP_006507478.1

    UniProtKB/Swiss-Prot
    Q9WUX5
    Conserved Domains (1) summary
    pfam05781
    Location:272856
    MRVI1; MRVI1 protein
  3. XM_036152758.1XP_036008651.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

    Conserved Domains (1) summary
    pfam05781
    Location:24608
    MRVI1; MRVI1 protein
  4. XM_006507418.5XP_006507481.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

    Conserved Domains (1) summary
    pfam05781
    Location:24608
    MRVI1; MRVI1 protein
  5. XM_011241686.1XP_011239988.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X1

    Related
    ENSMUSP00000120045.2, ENSMUST00000127935.8
    Conserved Domains (2) summary
    pfam05781
    Location:289873
    MRVI1; MRVI1 protein
    cl19857
    Location:122213
    DUF2126; Putative amidoligase enzyme (DUF2126)
  6. XM_011241687.4XP_011239989.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X4

    Conserved Domains (1) summary
    pfam05781
    Location:337490
    MRVI1; MRVI1 protein

RNA

  1. XR_869664.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010826.5: Suppressed sequence

    Description
    NM_010826.5: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.