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Mre11a MRE11A homolog A, double strand break repair nuclease [ Mus musculus (house mouse) ]

Gene ID: 17535, updated on 22-Sep-2022

Summary

Official Symbol
Mre11aprovided by MGI
Official Full Name
MRE11A homolog A, double strand break repair nucleaseprovided by MGI
Primary source
MGI:MGI:1100512
See related
Ensembl:ENSMUSG00000031928 AllianceGenome:MGI:1100512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mre11; Mre11b
Summary
Predicted to enable identical protein binding activity; nuclease activity; and protein C-terminus binding activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Colocalizes with chromosome, telomeric region. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.2), liver E14 (RPKM 3.7) and 28 other tissues See more
Orthologs
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Genomic context

See Mre11a in Genome Data Viewer
Location:
9; 9 A2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14695939..14753639)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14784654..14837125)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (14589151..14638861)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012B09 gene Neighboring gene ankyrin repeat domain 49 Neighboring gene macrophage migration inhibitory factor, pseudogene 6 Neighboring gene G protein-coupled receptor 83

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables 3'-5'-exodeoxyribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables 5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA double-strand break processing IC
Inferred by Curator
more info
PubMed 
involved_in DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA strand resection involved in replication fork processing IC
Inferred by Curator
more info
PubMed 
involved_in DNA strand resection involved in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homologous recombination IC
Inferred by Curator
more info
PubMed 
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2/M transition checkpoint IC
Inferred by Curator
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in telomeric 3' overhang formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BRCA1-C complex ISO
Inferred from Sequence Orthology
more info
 
part_of Mre11 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Mre11 complex ISO
Inferred from Sequence Orthology
more info
 
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosomal region IC
Inferred by Curator
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in replication fork ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
double-strand break repair protein MRE11
Names
MRE11 homolog 1
MRE11 homolog A
double-strand break repair protein MRE11A
meiotic recombination 11 homolog 1
meiotic recombination 11 homolog A
mmMRE11A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310728.2NP_001297657.1  double-strand break repair protein MRE11 isoform 2

    See identical proteins and their annotated locations for NP_001297657.1

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
    Consensus CDS
    CCDS80958.1
    UniProtKB/Swiss-Prot
    Q61216
    UniProtKB/TrEMBL
    Q3TU24, Q8BRV3
    Related
    ENSMUSP00000111295.4, ENSMUST00000115632.10
    Conserved Domains (1) summary
    cl27188
    Location:10375
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  2. NM_001411891.1NP_001398820.1  double-strand break repair protein MRE11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  3. NM_001411892.1NP_001398821.1  double-strand break repair protein MRE11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  4. NM_001411893.1NP_001398822.1  double-strand break repair protein MRE11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  5. NM_001411894.1NP_001398823.1  double-strand break repair protein MRE11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  6. NM_001411895.1NP_001398824.1  double-strand break repair protein MRE11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  7. NM_001411896.1NP_001398825.1  double-strand break repair protein MRE11 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  8. NM_001411897.1NP_001398826.1  double-strand break repair protein MRE11 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  9. NM_001411898.1NP_001398827.1  double-strand break repair protein MRE11 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  10. NM_001411899.1NP_001398828.1  double-strand break repair protein MRE11 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  11. NM_018736.4NP_061206.1  double-strand break repair protein MRE11 isoform 1

    See identical proteins and their annotated locations for NP_061206.1

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
    Consensus CDS
    CCDS22827.1
    UniProtKB/Swiss-Prot
    Q61216, Q62430
    UniProtKB/TrEMBL
    Q3TU24, Q3URU4
    Related
    ENSMUSP00000034405.5, ENSMUST00000034405.11
    Conserved Domains (1) summary
    cl27188
    Location:10402
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RNA

  1. NR_177972.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  2. NR_177973.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  3. NR_177974.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247
  4. NR_177975.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136743, CT030247

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    14695939..14753639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244083.2XP_030099943.1  double-strand break repair protein MRE11 isoform X4

    Conserved Domains (1) summary
    cl27188
    Location:3299
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  2. XM_006510048.4XP_006510111.1  double-strand break repair protein MRE11 isoform X1

    UniProtKB/Swiss-Prot
    Q61216, Q62430
    UniProtKB/TrEMBL
    Q3URU4
    Conserved Domains (1) summary
    cl27188
    Location:10402
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  3. XM_036154643.1XP_036010536.1  double-strand break repair protein MRE11 isoform X3

    Conserved Domains (1) summary
    cl27188
    Location:10340
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  4. XM_036154644.1XP_036010537.1  double-strand break repair protein MRE11 isoform X5

    Conserved Domains (1) summary
    cl27188
    Location:4246
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  5. XM_006510049.3XP_006510112.1  double-strand break repair protein MRE11 isoform X2

    UniProtKB/Swiss-Prot
    Q61216
    Conserved Domains (1) summary
    cl27188
    Location:10375
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  6. XM_006510051.2XP_006510114.1  double-strand break repair protein MRE11 isoform X3

    Conserved Domains (1) summary
    cl27188
    Location:10340
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  7. XM_006510053.2XP_006510116.1  double-strand break repair protein MRE11 isoform X5

    Conserved Domains (1) summary
    cl27188
    Location:4246
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  8. XM_006510054.2XP_006510117.1  double-strand break repair protein MRE11 isoform X6

    Conserved Domains (1) summary
    pfam04152
    Location:2169
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RNA

  1. XR_004935334.1 RNA Sequence

  2. XR_379107.3 RNA Sequence