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Mdh2 malate dehydrogenase 2, NAD (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 17448, updated on 27-Feb-2024

Summary

Official Symbol
Mdh2provided by MGI
Official Full Name
malate dehydrogenase 2, NAD (mitochondrial)provided by MGI
Primary source
MGI:MGI:97050
See related
Ensembl:ENSMUSG00000019179 AllianceGenome:MGI:97050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDH; Mor1; Mdh-2; Mor-1
Summary
Enables L-malate dehydrogenase activity. Predicted to be involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Located in membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 1627.0), heart adult (RPKM 883.1) and 27 other tissues See more
Orthologs
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Genomic context

See Mdh2 in Genome Data Viewer
Location:
5 G2; 5 75.4 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135807503..135819240)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135778649..135790386)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14588 Neighboring gene transmembrane protein 120A Neighboring gene STARR-positive B cell enhancer ABC_E9654 Neighboring gene microRNA 7034 Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136254330-136254517 Neighboring gene predicted gene, 30205 Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene STARR-positive B cell enhancer ABC_E6387 Neighboring gene predicted gene, 22450

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (6) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-malate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-malate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-malate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables malate dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables malate dehydrogenase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables malate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in NADH metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within malate metabolic process ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in malate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
malate dehydrogenase, mitochondrial
Names
mitochondrial malate dehydrogenase 2, NAD
NP_032643.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008617.2NP_032643.2  malate dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032643.2

    Status: PROVISIONAL

    Source sequence(s)
    BC023482
    Consensus CDS
    CCDS19746.1
    UniProtKB/Swiss-Prot
    P08249, Q0QF44, Q8CF79, Q8R1P0
    Related
    ENSMUSP00000019323.7, ENSMUST00000019323.11
    Conserved Domains (2) summary
    TIGR01772
    Location:26335
    MDH_euk_gproteo; malate dehydrogenase, NAD-dependent
    cd01337
    Location:26334
    MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135807503..135819240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)