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Mdh2 malate dehydrogenase 2, NAD (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 17448, updated on 9-Apr-2019

Summary

Official Symbol
Mdh2provided by MGI
Official Full Name
malate dehydrogenase 2, NAD (mitochondrial)provided by MGI
Primary source
MGI:MGI:97050
See related
Ensembl:ENSMUSG00000019179
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDH; Mor1; Mdh-2; Mor-1
Expression
Broad expression in duodenum adult (RPKM 1627.0), heart adult (RPKM 883.1) and 27 other tissues See more
Orthologs

Genomic context

See Mdh2 in Genome Data Viewer
Location:
5 G2; 5 75.4 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (135778649..135790386)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (136254519..136266256)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 120A Neighboring gene microRNA 7034 Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene uncharacterized LOC105244798 Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene heat shock protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
L-malate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
L-malate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
malate dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
malate dehydrogenase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
malate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NADH metabolic process ISO
Inferred from Sequence Orthology
more info
 
aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
internal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
 
malate metabolic process ISA
Inferred from Sequence Alignment
more info
PubMed 
malate metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial inner membrane HDA PubMed 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion ISA
Inferred from Sequence Alignment
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 

General protein information

Preferred Names
malate dehydrogenase, mitochondrial
Names
mitochondrial malate dehydrogenase 2, NAD
NP_032643.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008617.2NP_032643.2  malate dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032643.2

    Status: PROVISIONAL

    Source sequence(s)
    BC023482
    Consensus CDS
    CCDS19746.1
    UniProtKB/Swiss-Prot
    P08249
    Related
    ENSMUSP00000019323.6, ENSMUST00000019323.10
    Conserved Domains (2) summary
    TIGR01772
    Location:26335
    MDH_euk_gproteo; malate dehydrogenase, NAD-dependent
    cd01337
    Location:26334
    MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    135778649..135790386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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