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Mmp15 matrix metallopeptidase 15 [ Mus musculus (house mouse) ]

Gene ID: 17388, updated on 14-Apr-2018
Official Symbol
Mmp15provided by MGI
Official Full Name
matrix metallopeptidase 15provided by MGI
Primary source
MGI:MGI:109320
See related
Ensembl:ENSMUSG00000031790 Vega:OTTMUSG00000027464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MT2-MMP; AI503551; MT-MMP 2
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. A deficiency of the encoded protein in mice is compatible with normal development and postnatal growth. [provided by RefSeq, Feb 2016]
Expression
Broad expression in lung adult (RPKM 64.4), colon adult (RPKM 55.6) and 20 other tissues See more
Orthologs
See Mmp15 in Genome Data Viewer
Location:
8 C5; 8 47.12 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (95352296..95374293)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (97876237..97898193)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene testis, prostate and placenta expressed Neighboring gene zinc finger protein 319 Neighboring gene U6 snRNA biogenesis 1 Neighboring gene cilia and flagella associated protein 20 Neighboring gene casein kinase 2, alpha prime polypeptide

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
matrix metalloproteinase-15
Names
Membrane type 2-MMP
membrane-type-2 matrix metalloproteinase
NP_032635.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008609.4NP_032635.1  matrix metalloproteinase-15 preproprotein

    See identical proteins and their annotated locations for NP_032635.1

    Status: REVIEWED

    Source sequence(s)
    BC047278, BY732226
    Consensus CDS
    CCDS22561.1
    UniProtKB/Swiss-Prot
    O54732
    Related
    ENSMUSP00000034243.5, OTTMUSP00000034288, ENSMUST00000034243.6, OTTMUST00000067975
    Conserved Domains (5) summary
    cd00094
    Location:363555
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:135300
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:134300
    Peptidase_M10; Matrixin
    pfam01471
    Location:43102
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:632657
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    95352296..95374293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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