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Trpm1 transient receptor potential cation channel, subfamily M, member 1 [ Mus musculus (house mouse) ]

Gene ID: 17364, updated on 23-Apr-2024

Summary

Official Symbol
Trpm1provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 1provided by MGI
Primary source
MGI:MGI:1330305
See related
Ensembl:ENSMUSG00000030523 AllianceGenome:MGI:1330305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rd15; Mlsn1; Ltrpc1; 4732499L03Rik
Summary
Enables cation channel activity. Involved in cellular response to light stimulus. Acts upstream of or within cellular protein localization; retinal rod cell development; and signal transduction. Located in new growing cell tip. Is expressed in foregut; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in congenital stationary night blindness and congenital stationary night blindness 1C. Orthologous to human TRPM1 (transient receptor potential cation channel subfamily M member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
7 C; 7
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (63803583..63923630)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (64153835..64269772)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19029 Neighboring gene predicted gene 20670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:71246643-71247001 Neighboring gene predicted gene, 45988 Neighboring gene STARR-seq mESC enhancer starr_19032 Neighboring gene microRNA 211 Neighboring gene STARR-seq mESC enhancer starr_19035 Neighboring gene microRNA 6416 Neighboring gene STARR-seq mESC enhancer starr_19036 Neighboring gene myotubularin related protein 10 Neighboring gene STARR-seq mESC enhancer starr_19037 Neighboring gene STARR-seq mESC enhancer starr_19038 Neighboring gene SET translocation pseudogene Neighboring gene FANCD2/FANCI-associated nuclease 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in metal ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within retinal rod cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell tip IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in new growing cell tip IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily M member 1
Names
long transient receptor potential channel 1
melastatin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039104.2NP_001034193.2  transient receptor potential cation channel subfamily M member 1 isoform 2

    See identical proteins and their annotated locations for NP_001034193.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (TRPM1-L, PMID: 19966281, also known as Trpm1delta189-1078) differs in the 5' UTR and 5' coding region, and includes several additional exons at the 3' end, compared to variant 1. The resulting isoform (2) has distinct N- and C-termini, and is longer than isoform 1.
    Source sequence(s)
    AY180104
    Consensus CDS
    CCDS21332.2
    UniProtKB/Swiss-Prot
    O70334, Q2TV84, Q2WEA6, Q3TPG5, Q3UEW7, Q3UFV6, Q3UFW1, Q3UG69, Q5U4B3, Q640P5
    UniProtKB/TrEMBL
    A0A0U1RQ32
    Related
    ENSMUSP00000082318.6, ENSMUST00000085222.12
    Conserved Domains (3) summary
    pfam00520
    Location:8991129
    Ion_trans; Ion transport protein
    pfam16519
    Location:12281279
    TRPM_tetra; Tetramerization domain of TRPM
    cl19167
    Location:273342
    Bac_export_2; FlhB HrpN YscU SpaS Family
  2. NM_018752.3NP_061222.3  transient receptor potential cation channel subfamily M member 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (TRPM1-S, PMID: 19966281) encodes the shorter isoform (1).
    Source sequence(s)
    AF047714, AK148275, AK164395, AK190606, BB763853, BY100491
    Consensus CDS
    CCDS39975.2
    UniProtKB/Swiss-Prot
    Q2TV84
    Related
    ENSMUSP00000134947.3, ENSMUST00000177102.8
    Conserved Domains (1) summary
    pfam18139
    Location:1265
    LSDAT_euk; SLOG in TRPM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    63803583..63923630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322013.2XP_017177502.1  transient receptor potential cation channel subfamily M member 1 isoform X2

    UniProtKB/Swiss-Prot
    Q2TV84
    Conserved Domains (1) summary
    pfam18139
    Location:1265
    LSDAT_euk; SLOG in TRPM
  2. XM_017322012.3XP_017177501.1  transient receptor potential cation channel subfamily M member 1 isoform X1

    Conserved Domains (2) summary
    TIGR00870
    Location:97451
    trp; transient-receptor-potential calcium channel protein
    pfam16519
    Location:520575
    TRPM_tetra; Tetramerisation domain of TRPM