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Mid1 midline 1 [ Mus musculus (house mouse) ]

Gene ID: 17318, updated on 17-Mar-2024

Summary

Official Symbol
Mid1provided by MGI
Official Full Name
midline 1provided by MGI
Primary source
MGI:MGI:1100537
See related
Ensembl:ENSMUSG00000035299 AllianceGenome:MGI:1100537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fxy; 61B3-R; Trim18; DXHXS1141
Summary
Predicted to enable several functions, including microtubule binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; genitourinary system; and sensory organ. Used to study Opitz-GBBB syndrome and microphthalmia. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome type I. Orthologous to human MID1 (midline 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.3), cerebellum adult (RPKM 4.7) and 27 other tissues See more
Orthologs
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Genomic context

See Mid1 in Genome Data Viewer
Location:
X F5; X 79.19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (168468178..168773692)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (169685199..169990798)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15246 Neighboring gene STARR-seq mESC enhancer starr_48282 Neighboring gene predicted gene 15245 Neighboring gene STARR-seq mESC enhancer starr_48283 Neighboring gene predicted gene, 25651 Neighboring gene STARR-seq mESC enhancer starr_48284 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1B Neighboring gene predicted gene, 54065 Neighboring gene RIKEN cDNA G530011O06 gene Neighboring gene STARR-positive B cell enhancer mm9_chrX:166408204-166408505 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166407829-166408130 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166410801-166411102 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166413309-166413610 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166414802-166415103 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166415421-166415722 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166417053-166417354 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166417609-166417910 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166419073-166419374 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166420805-166421106 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166422120-166422421 Neighboring gene STARR-seq mESC enhancer starr_48290 Neighboring gene predicted gene 15247 Neighboring gene erythroid differentiation regulator 1 x Neighboring gene steroid sulfatase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC60591

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase Midline-1
Names
RING finger protein Midline-1
RING-type E3 ubiquitin transferase Midline-1
midin
tripartite motif-containing protein 18
NP_001277433.1
NP_001277434.1
NP_001277435.1
NP_001277441.1
NP_001412811.1
NP_001412812.1
NP_001412814.1
NP_001412815.1
NP_034927.2
XP_006528799.1
XP_006528800.1
XP_017173899.1
XP_017173900.1
XP_017173901.1
XP_017173902.1
XP_030107101.1
XP_030107103.1
XP_030107104.1
XP_036017723.1
XP_036017724.1
XP_036017725.1
XP_036017726.1
XP_036017727.1
XP_036017728.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290504.2NP_001277433.1  E3 ubiquitin-protein ligase Midline-1 isoform 2

    See identical proteins and their annotated locations for NP_001277433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 3, 4, and 9 all encode the same isoform (2).
    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    O70583
    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:485661
    SPRY; SPRY domain
  2. NM_001290505.2NP_001277434.1  E3 ubiquitin-protein ligase Midline-1 isoform 2

    See identical proteins and their annotated locations for NP_001277434.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 3, 4, and 9 all encode the same isoform (2).
    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    O70583
    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:485661
    SPRY; SPRY domain
  3. NM_001290506.2NP_001277435.1  E3 ubiquitin-protein ligase Midline-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses two alternate in-frame splice sites, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    O70583
    Conserved Domains (6) summary
    smart00502
    Location:182306
    BBC; B-Box C-terminal domain
    cd00063
    Location:357443
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:285336
    COS; TRIM C-terminal subgroup One Signature domain
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:447623
    SPRY; SPRY domain
  4. NM_001290512.2NP_001277441.1  E3 ubiquitin-protein ligase Midline-1 isoform 4

    See identical proteins and their annotated locations for NP_001277441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate in-frame splice site, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL671865, AL672015, CR478112
    UniProtKB/TrEMBL
    B1AUZ9, Q3TVH5
    Related
    ENSMUSP00000107735.2, ENSMUST00000112107.8
    Conserved Domains (3) summary
    cd00063
    Location:189275
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl02614
    Location:279455
    SPRY; SPRY domain
    cl23765
    Location:17138
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  5. NM_001425882.1NP_001412811.1  E3 ubiquitin-protein ligase Midline-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    B1AV00, O35418, O70583, Q7TPT6
  6. NM_001425883.1NP_001412812.1  E3 ubiquitin-protein ligase Midline-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672015, CR478112
    UniProtKB/Swiss-Prot
    B1AV00, O35418, O70583, Q7TPT6
  7. NM_001425885.1NP_001412814.1  E3 ubiquitin-protein ligase Midline-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671865, AL672015, CR478112
  8. NM_001425886.1NP_001412815.1  E3 ubiquitin-protein ligase Midline-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672015, CR478112
  9. NM_010797.4NP_034927.2  E3 ubiquitin-protein ligase Midline-1 isoform 1

    See identical proteins and their annotated locations for NP_034927.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 7, and 8 all encode the same isoform (1).
    Source sequence(s)
    AL671865, AL672015, CR478112
    Consensus CDS
    CCDS41215.1
    UniProtKB/Swiss-Prot
    B1AV00, O35418, O70583, Q7TPT6
    Related
    ENSMUSP00000107732.2, ENSMUST00000112104.8
    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395494
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:498674
    SPRY; SPRY domain

RNA

  1. NR_189632.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672015, CR478112

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    168468178..168773692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161833.1XP_036017726.1  E3 ubiquitin-protein ligase Midline-1 isoform X7

    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00162
    Location:1059
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:383559
    SPRY; SPRY domain
    cl17238
    Location:861
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_036161832.1XP_036017725.1  E3 ubiquitin-protein ligase Midline-1 isoform X7

    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00162
    Location:1059
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:383559
    SPRY; SPRY domain
    cl17238
    Location:861
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. XM_030251243.2XP_030107103.1  E3 ubiquitin-protein ligase Midline-1 isoform X5

    Conserved Domains (8) summary
    smart00502
    Location:191308
    BBC; B-Box C-terminal domain
    cd00063
    Location:359445
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:1059
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam18568
    Location:287338
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:449625
    SPRY; SPRY domain
    cl17238
    Location:861
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  4. XM_030251244.2XP_030107104.1  E3 ubiquitin-protein ligase Midline-1 isoform X6

    Conserved Domains (6) summary
    smart00502
    Location:182306
    BBC; B-Box C-terminal domain
    cd00063
    Location:357443
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:285336
    COS; TRIM C-terminal subgroup One Signature domain
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:447623
    SPRY; SPRY domain
  5. XM_036161835.1XP_036017728.1  E3 ubiquitin-protein ligase Midline-1 isoform X9

    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395494
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:1059
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cl17238
    Location:861
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  6. XM_036161834.1XP_036017727.1  E3 ubiquitin-protein ligase Midline-1 isoform X8

    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:485552
    SPRY; SPRY domain
  7. XM_036161831.1XP_036017724.1  E3 ubiquitin-protein ligase Midline-1 isoform X7

    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00162
    Location:1059
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:383559
    SPRY; SPRY domain
    cl17238
    Location:861
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  8. XM_017318411.3XP_017173900.1  E3 ubiquitin-protein ligase Midline-1 isoform X3

    Conserved Domains (8) summary
    smart00502
    Location:191308
    BBC; B-Box C-terminal domain
    cd00063
    Location:359458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:1059
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam18568
    Location:287338
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:462638
    SPRY; SPRY domain
    cl17238
    Location:861
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  9. XM_017318412.3XP_017173901.1  E3 ubiquitin-protein ligase Midline-1 isoform X4

    UniProtKB/TrEMBL
    B1AV01
    Related
    ENSMUSP00000077974.6, ENSMUST00000078947.12
    Conserved Domains (6) summary
    smart00502
    Location:182306
    BBC; B-Box C-terminal domain
    cd00063
    Location:357456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:285336
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:460636
    SPRY; SPRY domain
  10. XM_017318410.3XP_017173899.1  E3 ubiquitin-protein ligase Midline-1 isoform X1

    UniProtKB/Swiss-Prot
    B1AV00, O35418, O70583, Q7TPT6
    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395494
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:498674
    SPRY; SPRY domain
  11. XM_036161830.1XP_036017723.1  E3 ubiquitin-protein ligase Midline-1 isoform X4

    UniProtKB/TrEMBL
    B1AV01
    Conserved Domains (6) summary
    smart00502
    Location:182306
    BBC; B-Box C-terminal domain
    cd00063
    Location:357456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:285336
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:460636
    SPRY; SPRY domain
  12. XM_030251241.2XP_030107101.1  E3 ubiquitin-protein ligase Midline-1 isoform X2

    Conserved Domains (7) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00063
    Location:395481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd16753
    Location:861
    RING-HC_MID1; RING finger, HC subclass, found in midline-1 (MID1) and similar proteins
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:485661
    SPRY; SPRY domain
  13. XM_017318413.3XP_017173902.1  E3 ubiquitin-protein ligase Midline-1 isoform X13

    Conserved Domains (8) summary
    smart00502
    Location:219344
    BBC; B-Box C-terminal domain
    cd00063
    Location:472520
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:1059
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam18568
    Location:323374
    COS; TRIM C-terminal subgroup One Signature domain
    cd19822
    Location:168214
    Bbox2_MID1_C-I; B-box-type 2 zinc finger found in midline-1 (MID1) and similar proteins
    cd19836
    Location:115164
    Bbox1_MID1_C-I; B-box-type 1 zinc finger found in midline-1 (MID1) and similar proteins
    cl02614
    Location:524700
    SPRY; SPRY domain
    cl17238
    Location:861
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  14. XM_006528736.5XP_006528799.1  E3 ubiquitin-protein ligase Midline-1 isoform X10

    UniProtKB/TrEMBL
    B1AUZ9
    Conserved Domains (4) summary
    smart00502
    Location:2477
    BBC; B-Box C-terminal domain
    cd00063
    Location:128227
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18568
    Location:56107
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:231407
    SPRY; SPRY domain
  15. XM_006528737.5XP_006528800.1  E3 ubiquitin-protein ligase Midline-1 isoform X12

    See identical proteins and their annotated locations for XP_006528800.1

    UniProtKB/TrEMBL
    B1AUZ9, Q6PD02
    Related
    ENSMUSP00000078412.6, ENSMUST00000079443.6
    Conserved Domains (4) summary
    smart00502
    Location:2477
    BBC; B-Box C-terminal domain
    cd00063
    Location:128214
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18568
    Location:56107
    COS; TRIM C-terminal subgroup One Signature domain
    cl02614
    Location:218394
    SPRY; SPRY domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183151.1: Suppressed sequence

    Description
    NM_183151.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.