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Mgmt O-6-methylguanine-DNA methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 17314, updated on 12-Jun-2018
Official Symbol
Mgmtprovided by MGI
Official Full Name
O-6-methylguanine-DNA methyltransferaseprovided by MGI
Primary source
MGI:MGI:96977
See related
Ensembl:ENSMUSG00000054612 Vega:OTTMUSG00000060300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AGT; Agat; AI267024
Expression
Ubiquitous expression in liver adult (RPKM 5.7), subcutaneous fat pad adult (RPKM 5.0) and 24 other tissues See more
Orthologs
See Mgmt in Genome Data Viewer
Location:
7 F3; 7 82.07 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (136894468..137128193)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (144086294..144319871)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene 6249 Neighboring gene predicted gene, 29978 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene predicted gene, 39108 Neighboring gene predicted gene, 39109 Neighboring gene predicted gene, 30061

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Clone Names

  • MGC107020

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated-DNA-[protein]-cysteine S-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA dealkylation involved in DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
DNA dealkylation involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
methylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
methylated-DNA--protein-cysteine methyltransferase
Names
6-O-methylguanine-DNA methyltransferase
O-6-alkylguanine-DNA alkyltransferase
O-6-methylguanine-DNA-alkyltransferase
NP_032624.1
XP_006507468.1
XP_006507469.1
XP_006507470.1
XP_006507471.1
XP_006507472.1
XP_006507473.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008598.2NP_032624.1  methylated-DNA--protein-cysteine methyltransferase

    See identical proteins and their annotated locations for NP_032624.1

    Status: VALIDATED

    Source sequence(s)
    BC096557, BY344992
    Consensus CDS
    CCDS21945.1
    UniProtKB/Swiss-Prot
    P26187
    UniProtKB/TrEMBL
    Q4VA39
    Related
    ENSMUSP00000080224.2, OTTMUSP00000076809, ENSMUST00000081510.3, OTTMUST00000147589
    Conserved Domains (3) summary
    COG0350
    Location:6178
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    TIGR00589
    Location:97177
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:694
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    136894468..137128193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507406.1XP_006507469.1  methylated-DNA--protein-cysteine methyltransferase isoform X3

    Conserved Domains (3) summary
    COG0350
    Location:29201
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    TIGR00589
    Location:120200
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:29117
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
  2. XM_006507408.3XP_006507471.1  methylated-DNA--protein-cysteine methyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006507471.1

    Conserved Domains (3) summary
    COG0350
    Location:50199
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    TIGR00589
    Location:118198
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:65115
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
  3. XM_006507405.3XP_006507468.1  methylated-DNA--protein-cysteine methyltransferase isoform X2

    Conserved Domains (3) summary
    COG0350
    Location:38210
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    TIGR00589
    Location:129209
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:38126
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
  4. XM_006507409.3XP_006507472.1  methylated-DNA--protein-cysteine methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006507472.1

    UniProtKB/Swiss-Prot
    P26187
    Conserved Domains (3) summary
    COG0350
    Location:6178
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    TIGR00589
    Location:97177
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:694
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
  5. XM_006507410.3XP_006507473.1  methylated-DNA--protein-cysteine methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006507473.1

    UniProtKB/Swiss-Prot
    P26187
    Conserved Domains (3) summary
    COG0350
    Location:6178
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    TIGR00589
    Location:97177
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:694
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
  6. XM_006507407.2XP_006507470.1  methylated-DNA--protein-cysteine methyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006507470.1

    Conserved Domains (3) summary
    COG0350
    Location:50199
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    TIGR00589
    Location:118198
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:65115
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
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