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Mgmt O-6-methylguanine-DNA methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 17314, updated on 9-Mar-2023

Summary

Official Symbol
Mgmtprovided by MGI
Official Full Name
O-6-methylguanine-DNA methyltransferaseprovided by MGI
Primary source
MGI:MGI:96977
See related
Ensembl:ENSMUSG00000054612 AllianceGenome:MGI:96977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AGT; Agat
Summary
Enables methyltransferase activity. Acts upstream of or within DNA dealkylation involved in DNA repair and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; nervous system cancer (multiple); and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 5.7), subcutaneous fat pad adult (RPKM 5.0) and 24 other tissues See more
Orthologs
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Genomic context

See Mgmt in Genome Data Viewer
Location:
7 F3; 7 82.07 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (136496192..136729922)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (136894463..137128193)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6249 Neighboring gene predicted gene, 29978 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene predicted gene, 39108 Neighboring gene predicted gene, 30061 Neighboring gene early B cell factor 3 Neighboring gene predicted gene 10578

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107020

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methylated-DNA--protein-cysteine methyltransferase
Names
6-O-methylguanine-DNA methyltransferase
O-6-alkylguanine-DNA alkyltransferase
O-6-methylguanine-DNA-alkyltransferase
NP_001363966.1
NP_032624.1
XP_006507468.1
XP_006507469.1
XP_006507470.1
XP_006507471.1
XP_006507472.1
XP_036008634.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377037.2NP_001363966.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132594, AC135639, AC148997
    UniProtKB/Swiss-Prot
    Q54A49
    Conserved Domains (1) summary
    COG0350
    Location:6178
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
  2. NM_001412697.1NP_001399626.1  methylated-DNA--protein-cysteine methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132594, AC135639, AC148997
  3. NM_001412698.1NP_001399627.1  methylated-DNA--protein-cysteine methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  4. NM_001412699.1NP_001399628.1  methylated-DNA--protein-cysteine methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  5. NM_001412700.1NP_001399629.1  methylated-DNA--protein-cysteine methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  6. NM_001412701.1NP_001399630.1  methylated-DNA--protein-cysteine methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  7. NM_001412702.1NP_001399631.1  methylated-DNA--protein-cysteine methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  8. NM_001412703.1NP_001399632.1  methylated-DNA--protein-cysteine methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  9. NM_001412704.1NP_001399633.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132594, AC135639, AC148997
    UniProtKB/Swiss-Prot
    Q54A49
  10. NM_008598.4NP_032624.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_032624.1

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
    Consensus CDS
    CCDS21945.1
    UniProtKB/Swiss-Prot
    P26187, Q54A49
    UniProtKB/TrEMBL
    Q4VA39
    Related
    ENSMUSP00000080224.3, ENSMUST00000081510.4
    Conserved Domains (1) summary
    COG0350
    Location:6178
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]

RNA

  1. NR_182026.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  2. NR_182027.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  3. NR_182028.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132122, AC132594, AC135639, AC148997
  4. NR_182029.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132594, AC135639, AC148997

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    136496192..136729922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507406.2XP_006507469.1  methylated-DNA--protein-cysteine methyltransferase isoform X2

    Conserved Domains (1) summary
    COG0350
    Location:29201
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
  2. XM_006507408.5XP_006507471.1  methylated-DNA--protein-cysteine methyltransferase isoform X3

    Conserved Domains (2) summary
    TIGR00589
    Location:118198
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:65115
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
  3. XM_006507405.5XP_006507468.1  methylated-DNA--protein-cysteine methyltransferase isoform X1

    Conserved Domains (1) summary
    COG0350
    Location:38210
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
  4. XM_006507409.4XP_006507472.1  methylated-DNA--protein-cysteine methyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006507472.1

    UniProtKB/Swiss-Prot
    P26187, Q54A49
    Conserved Domains (1) summary
    COG0350
    Location:6178
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
  5. XM_036152741.1XP_036008634.1  methylated-DNA--protein-cysteine methyltransferase isoform X4

    Conserved Domains (1) summary
    COG0350
    Location:6178
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
  6. XM_006507407.2XP_006507470.1  methylated-DNA--protein-cysteine methyltransferase isoform X3

    Conserved Domains (2) summary
    TIGR00589
    Location:118198
    ogt; O-6-methylguanine DNA methyltransferase
    pfam02870
    Location:65115
    Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain