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Kitl kit ligand [ Mus musculus (house mouse) ]

Gene ID: 17311, updated on 21-Oct-2021

Summary

Official Symbol
Kitlprovided by MGI
Official Full Name
kit ligandprovided by MGI
Primary source
MGI:MGI:96974
See related
Ensembl:ENSMUSG00000019966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted
Expression
Ubiquitous expression in lung adult (RPKM 2.7), CNS E18 (RPKM 2.6) and 27 other tissues See more
Orthologs
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Genomic context

See Kitl in Genome Data Viewer
Location:
10 D1; 10 51.4 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (99851477..99936278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (100015615..100100416)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (99478458..99563046)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35437 Neighboring gene keratin 18 pseudogene Neighboring gene predicted gene, 35533 Neighboring gene THO complex 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables stem cell factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables stem cell factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within germ cell development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of mast cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neural crest cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAP kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of melanocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of myeloid leukocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kit ligand
Names
C-kit ligand
Steel factor
cloud gray
grizzle-belly
hematopoietic growth factor KL
mast cell growth factor
stem cell factor
NP_001334085.1
NP_038626.1
XP_006513377.1
XP_006513378.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347156.1NP_001334085.1  kit ligand isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct internal amino acid and is shorter than isoform 1.
    Source sequence(s)
    AC159910, BU700928, U44725
    Consensus CDS
    CCDS83751.1
    UniProtKB/Swiss-Prot
    P20826
    Related
    ENSMUSP00000020129.8, ENSMUST00000020129.8
  2. NM_013598.3NP_038626.1  kit ligand isoform 1 precursor

    See identical proteins and their annotated locations for NP_038626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159910, BU700928, U44725
    Consensus CDS
    CCDS36046.1
    UniProtKB/Swiss-Prot
    P20826
    Related
    ENSMUSP00000100920.2, ENSMUST00000105283.9
    Conserved Domains (1) summary
    pfam02404
    Location:1273
    SCF; Stem cell factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    99851477..99936278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513314.5XP_006513377.1  kit ligand isoform X1

    Conserved Domains (1) summary
    pfam02404
    Location:46313
    SCF; Stem cell factor
  2. XM_006513315.4XP_006513378.1  kit ligand isoform X2

    Conserved Domains (1) summary
    pfam02404
    Location:46285
    SCF; Stem cell factor
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