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Mettl1 methyltransferase 1, tRNA methylguanosine [ Mus musculus (house mouse) ]

Gene ID: 17299, updated on 4-May-2024

Summary

Official Symbol
Mettl1provided by MGI
Official Full Name
methyltransferase 1, tRNA methylguanosineprovided by MGI
Primary source
MGI:MGI:1339986
See related
Ensembl:ENSMUSG00000006732 AllianceGenome:MGI:1339986
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810012D02Rik
Summary
Predicted to enable tRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in RNA (guanine-N7)-methylation and tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.7), placenta adult (RPKM 9.1) and 28 other tissues See more
Orthologs
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Genomic context

See Mettl1 in Genome Data Viewer
Location:
10 D3; 10 74.5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126877287..126882234)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127041549..127046365)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane associated ring-CH-type finger 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables internal mRNA (guanine-N7-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA (guanine(46)-N7)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA (guanine-N7)-methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in RNA (guanine-N7)-methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA (guanine-N7)-methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of tRNA (m7G46) methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of tRNA methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
tRNA (guanine-N(7)-)-methyltransferase
Names
mRNA (guanine-N(7)-)-methyltransferase
methyltransferase like 1
miRNA (guanine-N(7)-)-methyltransferase
NP_034922.1
XP_006513375.1
XP_006513376.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010792.1NP_034922.1  tRNA (guanine-N(7)-)-methyltransferase

    See identical proteins and their annotated locations for NP_034922.1

    Status: PROVISIONAL

    Source sequence(s)
    AB023619
    Consensus CDS
    CCDS24223.1
    UniProtKB/Swiss-Prot
    Q3TU83, Q921G5, Q9Z120
    Related
    ENSMUSP00000006915.8, ENSMUST00000006915.14
    Conserved Domains (1) summary
    pfam02390
    Location:71248
    Methyltransf_4; Putative methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    126877287..126882234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513312.3XP_006513375.1  tRNA (guanine-N(7)-)-methyltransferase isoform X1

    Conserved Domains (1) summary
    pfam02390
    Location:118295
    Methyltransf_4; Putative methyltransferase
  2. XM_006513313.4XP_006513376.1  tRNA (guanine-N(7)-)-methyltransferase isoform X2

    UniProtKB/TrEMBL
    D3Z7D2
    Related
    ENSMUSP00000113030.2, ENSMUST00000120542.8
    Conserved Domains (1) summary
    cl17173
    Location:118232
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...