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Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 [ Mus musculus (house mouse) ]

Gene ID: 17254, updated on 5-Feb-2023

Summary

Official Symbol
Slc3a2provided by MGI
Official Full Name
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2provided by MGI
Primary source
MGI:MGI:96955
See related
Ensembl:ENSMUSG00000010095 AllianceGenome:MGI:96955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4F2; Cd98; Ly10; Mdu1; 4F2HC; Ly-10; NACAE; Ly-m10; Mgp-2hc
Summary
Predicted to enable amino acid transmembrane transporter activity and double-stranded RNA binding activity. Predicted to be involved in carboxylic acid transport and viral entry into host cell. Predicted to act upstream of or within response to exogenous dsRNA. Located in apical pole of neuron. Is active in synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Orthologous to human SLC3A2 (solute carrier family 3 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 55.8), genital fat pad adult (RPKM 41.8) and 28 other tissues See more
Orthologs
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Genomic context

See Slc3a2 in Genome Data Viewer
Location:
19 A; 19 5.44 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8684246..8700733, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8706882..8723369, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9830166K06 gene Neighboring gene cholinergic receptor, muscarinic 1, CNS Neighboring gene predicted gene, 25855 Neighboring gene predicted gene, 25894 Neighboring gene small nucleolar RNA host gene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in L-alanine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-alanine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in L-histidine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in L-leucine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-leucine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in isoleucine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in leucine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in leucine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leucine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in methionine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in phenylalanine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phenylalanine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in thyroid hormone transport ISO
Inferred from Sequence Orthology
more info
 
involved_in tryptophan transport ISO
Inferred from Sequence Orthology
more info
 
involved_in tyrosine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in valine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of amino acid transport complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical pole of neuron IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
4F2 cell-surface antigen heavy chain
Names
CD98 antigen
CD98 heavy chain
antigen identified by monoclonal antibodies 4F2
solute carrier family 3 member 2
type II transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161413.2NP_001154885.1  4F2 cell-surface antigen heavy chain isoform a

    See identical proteins and their annotated locations for NP_001154885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
    Source sequence(s)
    AC025794
    Consensus CDS
    CCDS50381.1
    UniProtKB/Swiss-Prot
    P10852
    Related
    ENSMUSP00000130194.2, ENSMUST00000170157.8
    Conserved Domains (3) summary
    COG0366
    Location:169513
    AmyA; Glycosidase [Carbohydrate transport and metabolism]
    pfam16028
    Location:85156
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus
    cl07893
    Location:139468
    AmyAc_family; Alpha amylase catalytic domain family
  2. NM_001410771.1NP_001397700.1  4F2 cell-surface antigen heavy chain isoform b

    Status: VALIDATED

    Source sequence(s)
    AC025794
    UniProtKB/Swiss-Prot
    Q54AH5
  3. NM_008577.5NP_032603.3  4F2 cell-surface antigen heavy chain isoform b

    See identical proteins and their annotated locations for NP_032603.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' coding region and 5' UTR, compared to variant 1. This results in a shorter and distinct N-terminus in isoform b, compared to isoform a.
    Source sequence(s)
    AC025794
    Consensus CDS
    CCDS29540.1
    UniProtKB/Swiss-Prot
    P10852, Q54AH5
    Related
    ENSMUSP00000010239.5, ENSMUST00000010239.6
    Conserved Domains (2) summary
    pfam16028
    Location:45118
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus
    cl38930
    Location:100429
    AmyAc_family; Alpha amylase catalytic domain family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8684246..8700733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318078.3XP_017173567.1  4F2 cell-surface antigen heavy chain isoform X1

    UniProtKB/Swiss-Prot
    P10852, Q54AH5
    Conserved Domains (2) summary
    pfam16028
    Location:45118
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus
    cl38930
    Location:100429
    AmyAc_family; Alpha amylase catalytic domain family
  2. XM_036161455.1XP_036017348.1  4F2 cell-surface antigen heavy chain isoform X1

    Conserved Domains (2) summary
    pfam16028
    Location:45118
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus
    cl38930
    Location:100429
    AmyAc_family; Alpha amylase catalytic domain family
  3. XM_006526733.4XP_006526796.1  4F2 cell-surface antigen heavy chain isoform X2

    UniProtKB/TrEMBL
    A0A0U1RPK4
    Related
    ENSMUSP00000146016.2, ENSMUST00000206598.2
    Conserved Domains (2) summary
    TIGR02403
    Location:179297
    trehalose_treC; alpha,alpha-phosphotrehalase
    cl38930
    Location:1206
    AmyAc_family; Alpha amylase catalytic domain family