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Mdm2 transformed mouse 3T3 cell double minute 2 [ Mus musculus (house mouse) ]

Gene ID: 17246, updated on 3-Jun-2018
Official Symbol
Mdm2provided by MGI
Official Full Name
transformed mouse 3T3 cell double minute 2provided by MGI
Primary source
MGI:MGI:96952
See related
Ensembl:ENSMUSG00000020184 Vega:OTTMUSG00000020921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mdm-2; AA415488; 1700007J15Rik
Expression
Ubiquitous expression in testis adult (RPKM 10.8), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
Orthologs
See Mdm2 in Genome Data Viewer
Location:
10 D2; 10 66.32 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (117688875..117710758, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (117125961..117147772, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32365 Neighboring gene carboxypeptidase M Neighboring gene solute carrier family 35, member E3 Neighboring gene nucleoporin 107

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
5S rRNA binding ISO
Inferred from Sequence Orthology
more info
 
NEDD8 ligase activity ISO
Inferred from Sequence Orthology
more info
 
SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
 
disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ligase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
receptor serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
atrial septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
atrioventricular valve morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to actinomycin D ISO
Inferred from Sequence Orthology
more info
 
cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart valve development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein processing ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
peptidyl-lysine modification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart rate IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
response to water-immersion restraint stress ISO
Inferred from Sequence Orthology
more info
 
traversing start control point of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
ventricular septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
E3 ubiquitin-protein ligase Mdm2
Names
RING-type E3 ubiquitin transferase Mdm2
double minute 2 protein
oncoprotein Mdm2
p53-binding protein Mdm2
NP_001275515.1
NP_034916.1
XP_017169311.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288586.2NP_001275515.1  E3 ubiquitin-protein ligase Mdm2 isoform 2

    See identical proteins and their annotated locations for NP_001275515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC050902, BP767471, BY323121, CN703560
    Consensus CDS
    CCDS70110.1
    UniProtKB/Swiss-Prot
    P23804
    Related
    ENSMUSP00000100898.1, OTTMUSP00000022917, ENSMUST00000105263.8, OTTMUST00000049453
    Conserved Domains (3) summary
    pfam00641
    Location:248277
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:143
    SWIB; SWIB/MDM2 domain
    pfam13920
    Location:385432
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_010786.4NP_034916.1  E3 ubiquitin-protein ligase Mdm2 isoform 1

    See identical proteins and their annotated locations for NP_034916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK004719, BP767471, BY323121
    Consensus CDS
    CCDS24194.1
    UniProtKB/Swiss-Prot
    P23804
    Related
    ENSMUSP00000020408.8, OTTMUSP00000022916, ENSMUST00000020408.15, OTTMUST00000049452
    Conserved Domains (3) summary
    pfam00641
    Location:297326
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:4692
    SWIB; SWIB/MDM2 domain
    pfam13920
    Location:434481
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    117688875..117710758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313822.1XP_017169311.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

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