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Mal myelin and lymphocyte protein, T cell differentiation protein [ Mus musculus (house mouse) ]

Gene ID: 17153, updated on 13-Oct-2022

Summary

Official Symbol
Malprovided by MGI
Official Full Name
myelin and lymphocyte protein, T cell differentiation proteinprovided by MGI
Primary source
MGI:MGI:892970
See related
Ensembl:ENSMUSG00000027375 AllianceGenome:MGI:892970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpv17; Vip17
Summary
This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Expression
Biased expression in bladder adult (RPKM 46.2), stomach adult (RPKM 45.2) and 10 other tissues See more
Orthologs
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Genomic context

See Mal in Genome Data Viewer
Location:
2; 2 F1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127475146..127498615, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127633226..127656695, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 661 Neighboring gene mitochondrial ribosomal protein S5 Neighboring gene predicted gene, 22889 Neighboring gene poly (A) polymerase alpha pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of myelin sheath ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Schmidt-Lanterman incisure ISO
Inferred from Sequence Orthology
more info
 
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in hinge region between urothelial plaques of apical plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane raft IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
myelin and lymphocyte protein
Names
T-lymphocyte maturation-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171187.1NP_001164658.1  myelin and lymphocyte protein isoform 2

    See identical proteins and their annotated locations for NP_001164658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK019046, AK158653, BY626921
    Consensus CDS
    CCDS50705.1
    UniProtKB/Swiss-Prot
    O09198
    Related
    ENSMUSP00000028853.7, ENSMUST00000028853.7
  2. NM_010762.5NP_034892.1  myelin and lymphocyte protein isoform 1

    See identical proteins and their annotated locations for NP_034892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK158653, BY626921
    Consensus CDS
    CCDS16707.1
    UniProtKB/Swiss-Prot
    O09198, Q9D2R2
    UniProtKB/TrEMBL
    A0A8C6HJ53
    Related
    ENSMUSP00000028854.9, ENSMUST00000028854.15
    Conserved Domains (1) summary
    pfam01284
    Location:19145
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127475146..127498615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)