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Smad7 SMAD family member 7 [ Mus musculus (house mouse) ]

Gene ID: 17131, updated on 27-Feb-2024

Summary

Official Symbol
Smad7provided by MGI
Official Full Name
SMAD family member 7provided by MGI
Primary source
MGI:MGI:1100518
See related
Ensembl:ENSMUSG00000025880 AllianceGenome:MGI:1100518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Madh7
Summary
Enables collagen binding activity. Involved in several processes, including circulatory system development; negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and negative regulation of protein phosphorylation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of BMP signaling pathway; and transforming growth factor beta receptor signaling pathway. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 44.6), small intestine adult (RPKM 23.7) and 23 other tissues See more
Orthologs
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Genomic context

See Smad7 in Genome Data Viewer
Location:
18 E3; 18 51.06 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (75500436..75529006)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (75367365..75395935)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010010A06 gene Neighboring gene STARR-seq mESC enhancer starr_45046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:75464300-75464409 Neighboring gene STARR-positive B cell enhancer ABC_E7611 Neighboring gene STARR-seq mESC enhancer starr_45057 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:75513492-75513601 Neighboring gene STARR-seq mESC enhancer starr_45059 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:75537151-75537467 Neighboring gene STARR-seq mESC enhancer starr_45061 Neighboring gene predicted gene 20544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:75579115-75579397 Neighboring gene predicted gene, 41776 Neighboring gene STARR-seq mESC enhancer starr_45075 Neighboring gene CBP80/20-dependent translation initiation factor Neighboring gene predicted gene, 52357 Neighboring gene VISTA enhancers mm18 and mm257 Neighboring gene predicted gene 10532

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (9)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription regulator inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adherens junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T-helper 17 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chondrocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by competitive promoter binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chondrocyte hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane depolarization IC
Inferred by Curator
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ureteric bud development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 7
Names
MAD homolog 7
MAD homolog 8
SMAD 7
madh8
mothers against DPP homolog 7
mothers against DPP homolog 8
mothers against decapentaplegic homolog 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042660.1NP_001036125.1  mothers against decapentaplegic homolog 7

    See identical proteins and their annotated locations for NP_001036125.1

    Status: VALIDATED

    Source sequence(s)
    AC120156, AJ000550
    Consensus CDS
    CCDS37860.1
    UniProtKB/Swiss-Prot
    O35253, O88709
    UniProtKB/TrEMBL
    B2RPW6
    Related
    ENSMUSP00000026999.4, ENSMUST00000026999.10
    Conserved Domains (2) summary
    cd10494
    Location:60205
    MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7
    cd10500
    Location:254424
    MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    75500436..75529006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525703.3XP_006525766.1  mothers against decapentaplegic homolog 7 isoform X1

    See identical proteins and their annotated locations for XP_006525766.1

    UniProtKB/Swiss-Prot
    O35253
    Conserved Domains (2) summary
    cd10494
    Location:60205
    MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7
    cd10500
    Location:253423
    MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7
  2. XM_036161005.1XP_036016898.1  mothers against decapentaplegic homolog 7 isoform X2

    Conserved Domains (2) summary
    cd10494
    Location:60205
    MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7
    cd10500
    Location:229399
    MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008543.1: Suppressed sequence

    Description
    NM_008543.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate, and there is no transcriptional support for this variant.