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Smad4 SMAD family member 4 [ Mus musculus (house mouse) ]

Gene ID: 17128, updated on 27-Feb-2024

Summary

Official Symbol
Smad4provided by MGI
Official Full Name
SMAD family member 4provided by MGI
Primary source
MGI:MGI:894293
See related
Ensembl:ENSMUSG00000024515 AllianceGenome:MGI:894293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DPC4; Madh4; D18Wsu70e
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; collagen binding activity; and identical protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; heart development; and positive regulation of protein modification process. Acts upstream of or within several processes, including animal organ development; positive regulation of gonadotropin secretion; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and respiratory system. Used to study juvenile polyposis syndrome and osteogenesis imperfecta. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 11.7), CNS E11.5 (RPKM 11.4) and 28 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Smad4 in Genome Data Viewer
Location:
18 E2; 18 49.51 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73767861..73836862, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73634790..73703791, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32022 Neighboring gene STARR-seq mESC enhancer starr_44988 Neighboring gene STARR-positive B cell enhancer ABC_E777 Neighboring gene mex3 RNA binding family member C Neighboring gene STARR-seq mESC enhancer starr_44990 Neighboring gene STARR-seq mESC enhancer starr_44991 Neighboring gene STARR-seq mESC enhancer starr_44992 Neighboring gene RIKEN cDNA 4930578L24 gene Neighboring gene STARR-positive B cell enhancer ABC_E7608 Neighboring gene STARR-seq mESC enhancer starr_44993 Neighboring gene predicted gene, 32548

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables collagen binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables filamin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in activin receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within anatomical structure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular canal development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in atrioventricular valve formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brainstem development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within female gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within female gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within formation of anatomical boundary IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in left ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mesendoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric mesenchyme morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nephrogenic mesenchyme morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron fate specification ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell proliferation involved in heart valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of follicle-stimulating hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of follicle-stimulating hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of luteinizing hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of luteinizing hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of miRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of binding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transforming growth factor beta2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to transforming growth factor beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sebaceous gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within single fertilization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somite rostral/caudal axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within uterus development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of activin responsive factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heteromeric SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of heteromeric SMAD protein complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 4
Names
MAD homolog 4
deletion target in pancreatic carcinoma 4 homolog
mothers against DPP homolog 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364967.1NP_001351896.1  mothers against decapentaplegic homolog 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134447, BC046584, BY742922, GU072917
    UniProtKB/TrEMBL
    E3SRG7
    Conserved Domains (2) summary
    cd10492
    Location:14138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:240357
    MH2; C-terminal Mad Homology 2 (MH2) domain
  2. NM_001364968.1NP_001351897.1  mothers against decapentaplegic homolog 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134447, BC046584, BY742922, GU072918
    UniProtKB/TrEMBL
    E3SRG8, Q811W8
    Conserved Domains (2) summary
    cd10492
    Location:14138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:223444
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4
  3. NM_008540.3NP_032566.2  mothers against decapentaplegic homolog 4 isoform 1

    See identical proteins and their annotated locations for NP_032566.2

    Status: VALIDATED

    Source sequence(s)
    AC134447, BC046584, BY742922
    Consensus CDS
    CCDS29337.1
    UniProtKB/Swiss-Prot
    P97471, Q6GTP6, Q9CW56
    UniProtKB/TrEMBL
    Q811W8
    Related
    ENSMUSP00000025393.8, ENSMUST00000025393.14
    Conserved Domains (2) summary
    cd10492
    Location:14138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:319540
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

RNA

  1. NR_157374.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132418, AC134447

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    73767861..73836862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246855.3XP_011245157.1  mothers against decapentaplegic homolog 4 isoform X1

    UniProtKB/TrEMBL
    E3SRH0
    Conserved Domains (2) summary
    cd10492
    Location:14138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:319436
    MH2; C-terminal Mad Homology 2 (MH2) domain
  2. XM_006525701.4XP_006525764.1  mothers against decapentaplegic homolog 4 isoform X2

    UniProtKB/TrEMBL
    Q811W8
    Conserved Domains (2) summary
    cd10492
    Location:14138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:240461
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4