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Asic3 acid-sensing ion channel 3 [ Mus musculus (house mouse) ]

Gene ID: 171209, updated on 18-Apr-2024

Summary

Official Symbol
Asic3provided by MGI
Official Full Name
acid-sensing ion channel 3provided by MGI
Primary source
MGI:MGI:2159339
See related
Ensembl:ENSMUSG00000038276 AllianceGenome:MGI:2159339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Accn3; TNAC1; DRASIC; SLNAC1
Summary
Enables cation channel activity and enterobactin transmembrane transporter activity. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to acidic pH; and response to heat. Is integral component of plasma membrane. Is expressed in cranial ganglion; dorsal root ganglion; and pectoral girdle and thoracic body wall muscle. Orthologous to human ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
5 A3; 5 11.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24618449..24622836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24413451..24417840)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 3, endothelial cell Neighboring gene autophagy related 9B Neighboring gene STARR-positive B cell enhancer ABC_E4747 Neighboring gene STARR-positive B cell enhancer ABC_E1677 Neighboring gene ATP-binding cassette, sub-family B member 8 Neighboring gene cyclin dependent kinase 5 Neighboring gene STARR-positive B cell enhancer ABC_E9251 Neighboring gene solute carrier family 4 (anion exchanger), member 2 Neighboring gene predicted gene, 22333 Neighboring gene Fas-activated serine/threonine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enterobactin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ligand-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monoatomic cation channel activity TAS
Traceable Author Statement
more info
PubMed 
enables pH-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sour taste ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acid-sensing ion channel 3
Names
acid-sensing (proton-gated) ion channel 3
amiloride-sensitive cation channel 3
dorsal root ASIC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310474.1NP_001297403.1  acid-sensing ion channel 3 isoform 2

    See identical proteins and their annotated locations for NP_001297403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK028403, BC054460
    Consensus CDS
    CCDS80225.1
    UniProtKB/Swiss-Prot
    Q6X1Y6
    Related
    ENSMUSP00000039914.7, ENSMUST00000049346.10
    Conserved Domains (1) summary
    cl02990
    Location:21355
    ASC; Amiloride-sensitive sodium channel
  2. NM_183000.2NP_892045.2  acid-sensing ion channel 3 isoform 1

    See identical proteins and their annotated locations for NP_892045.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC054460
    Consensus CDS
    CCDS51433.1
    UniProtKB/Swiss-Prot
    Q6X1Y6, Q7TQH4
    Related
    ENSMUSP00000143083.2, ENSMUST00000196296.2
    Conserved Domains (1) summary
    cl02990
    Location:21513
    ASC; Amiloride-sensitive sodium channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24618449..24622836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535637.4XP_006535700.1  acid-sensing ion channel 3 isoform X1

    Conserved Domains (1) summary
    cl02990
    Location:21546
    ASC; Amiloride-sensitive sodium channel
  2. XM_006535638.4XP_006535701.1  acid-sensing ion channel 3 isoform X2

    Conserved Domains (1) summary
    cl02990
    Location:21483
    ASC; Amiloride-sensitive sodium channel
  3. XM_017320697.3XP_017176186.1  acid-sensing ion channel 3 isoform X3

    Conserved Domains (1) summary
    cl02990
    Location:21355
    ASC; Amiloride-sensitive sodium channel

RNA

  1. XR_389741.5 RNA Sequence