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M6pr mannose-6-phosphate receptor, cation dependent [ Mus musculus (house mouse) ]

Gene ID: 17113, updated on 26-Sep-2022

Summary

Official Symbol
M6prprovided by MGI
Official Full Name
mannose-6-phosphate receptor, cation dependentprovided by MGI
Primary source
MGI:MGI:96904
See related
Ensembl:ENSMUSG00000007458 AllianceGenome:MGI:96904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpr46; CD-MPR
Summary
Predicted to enable retromer complex binding activity. Involved in lysosomal transport. Acts upstream of or within secretion of lysosomal enzymes. Located in late endosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and skin. Orthologous to human M6PR (mannose-6-phosphate receptor, cation dependent). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 50.8), bladder adult (RPKM 46.6) and 28 other tissues See more
Orthologs
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Genomic context

See M6pr in Genome Data Viewer
Location:
6 F1; 6 57.52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122285679..122294639)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122308720..122317680)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53340 Neighboring gene predicted gene 6637 Neighboring gene polyhomeotic 1 Neighboring gene RIKEN cDNA 1700063H04 gene Neighboring gene VISTA enhancer mm94

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cation-dependent mannose-6-phosphate receptor
Names
46 kDa mannose 6-phosphate receptor
CD Man-6-P receptor
MPR 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010749.7NP_034879.2  cation-dependent mannose-6-phosphate receptor precursor

    See identical proteins and their annotated locations for NP_034879.2

    Status: VALIDATED

    Source sequence(s)
    AK153302, BC046956, CF730051
    Consensus CDS
    CCDS20493.1
    UniProtKB/Swiss-Prot
    P24668
    UniProtKB/TrEMBL
    A0A8C6N4C0, Q3UKQ5
    Related
    ENSMUSP00000007602.9, ENSMUST00000007602.15
    Conserved Domains (1) summary
    pfam02157
    Location:1278
    Man-6-P_recep; Mannose-6-phosphate receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122285679..122294639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)