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Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [ Mus musculus (house mouse) ]

Gene ID: 170750, updated on 5-Feb-2023

Summary

Official Symbol
Xpnpep1provided by MGI
Official Full Name
X-prolyl aminopeptidase (aminopeptidase P) 1, solubleprovided by MGI
Primary source
MGI:MGI:2180003
See related
Ensembl:ENSMUSG00000025027 AllianceGenome:MGI:2180003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sAMP; D230045I08Rik
Summary
Predicted to enable manganese ion binding activity; metalloaminopeptidase activity; and protein homodimerization activity. Predicted to be involved in bradykinin catabolic process and proteolysis. Predicted to be located in cytosol. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 157.6), small intestine adult (RPKM 86.1) and 28 other tissues See more
Orthologs
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Genomic context

See Xpnpep1 in Genome Data Viewer
Location:
19; 19 D2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (52919710..53027093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (52931279..53038662, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41860 Neighboring gene expressed sequence AA387883 Neighboring gene predicted gene, 41861 Neighboring gene microRNA 6407 Neighboring gene RIKEN cDNA 1700054A03 gene Neighboring gene predicted gene, 54048 Neighboring gene predicted gene, 30234

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
xaa-Pro aminopeptidase 1
Names
X-Pro aminopeptidase 1
aminoacylproline aminopeptidase
cytosolic aminopeptidase P
NP_001361763.1
NP_573479.3
XP_011245460.1
XP_011245461.1
XP_017173564.1
XP_030106621.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374834.1NP_001361763.1  xaa-Pro aminopeptidase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163221
    Consensus CDS
    CCDS89415.1
    UniProtKB/Swiss-Prot
    Q91Y37
    UniProtKB/TrEMBL
    Q3UKF5
    Conserved Domains (4) summary
    cd01085
    Location:329551
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:557618
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:157326
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:10154
    Creatinase_N; Creatinase/Prolidase N-terminal domain
  2. NM_133216.4NP_573479.3  xaa-Pro aminopeptidase 1 isoform 1

    See identical proteins and their annotated locations for NP_573479.3

    Status: VALIDATED

    Source sequence(s)
    AC163221
    Consensus CDS
    CCDS29899.2
    UniProtKB/Swiss-Prot
    Q6P1B1
    UniProtKB/TrEMBL
    Q3UE92
    Related
    ENSMUSP00000138250.2, ENSMUST00000183108.8
    Conserved Domains (4) summary
    cd01085
    Location:372594
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:600661
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:200369
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:53197
    Creatinase_N; Creatinase/Prolidase N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    52919710..53027093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247158.3XP_011245460.1  xaa-Pro aminopeptidase 1 isoform X1

    Conserved Domains (4) summary
    cd01085
    Location:372594
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:600624
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:200369
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:53197
    Creatinase_N; Creatinase/Prolidase N-terminal domain
  2. XM_030250761.2XP_030106621.1  xaa-Pro aminopeptidase 1 isoform X3

    UniProtKB/TrEMBL
    A0A494BBG8
    Related
    ENSMUSP00000158501.2, ENSMUST00000236008.2
    Conserved Domains (4) summary
    cd01085
    Location:329551
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:557581
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:157326
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:10154
    Creatinase_N; Creatinase/Prolidase N-terminal domain
  3. XM_011247159.2XP_011245461.1  xaa-Pro aminopeptidase 1 isoform X2

    See identical proteins and their annotated locations for XP_011245461.1

    UniProtKB/Swiss-Prot
    Q6P1B1, Q91Y37
    UniProtKB/TrEMBL
    Q3UKF5
    Related
    ENSMUSP00000158390.2, ENSMUST00000237294.2
    Conserved Domains (4) summary
    cd01085
    Location:329551
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:557618
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:157326
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:10154
    Creatinase_N; Creatinase/Prolidase N-terminal domain
  4. XM_017318075.3XP_017173564.1  xaa-Pro aminopeptidase 1 isoform X4

    Related
    ENSMUST00000182877.8
    Conserved Domains (3) summary
    cd01085
    Location:258480
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:486547
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:86255
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain