U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Epcam epithelial cell adhesion molecule [ Mus musculus (house mouse) ]

Gene ID: 17075, updated on 18-Jun-2024

Summary

Official Symbol
Epcamprovided by MGI
Official Full Name
epithelial cell adhesion moleculeprovided by MGI
Primary source
MGI:MGI:106653
See related
Ensembl:ENSMUSG00000045394 AllianceGenome:MGI:106653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EGP; Ly74; gp40; CD326; EGP-2; TROP1; Egp314; Ep-CAM; EpCAM1; Tacsd1; GA733-2; Tacstd1
Summary
Predicted to enable cadherin binding activity involved in cell-cell adhesion. Acts upstream of or within ureteric bud development. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diarrhea 5 with tufting enteropathy. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 346.5), colon adult (RPKM 315.1) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Epcam in Genome Data Viewer
Location:
17 E4; 17 57.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87943407..87958555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87635979..87651127)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1949 Neighboring gene predicted gene, 46587 Neighboring gene predicted gene, 46609 Neighboring gene STARR-seq mESC enhancer starr_43514 Neighboring gene STARR-positive B cell enhancer ABC_E7565 Neighboring gene STARR-seq mESC enhancer starr_43516 Neighboring gene mutS homolog 2 Neighboring gene STARR-seq mESC enhancer starr_43518 Neighboring gene STARR-seq mESC enhancer starr_43519 Neighboring gene potassium channel, subfamily K, member 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding involved in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cadherin binding involved in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
epithelial cell adhesion molecule
Names
Trop-1 protein
epithelial glycoprotein 314
lymphocyte antigen 74
mEGP314
panepithelial glycoprotein 314
protein 289A
tumor-associated calcium signal transducer 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008532.2NP_032558.2  epithelial cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_032558.2

    Status: VALIDATED

    Source sequence(s)
    AK133510, AK167182, BI986346
    Consensus CDS
    CCDS29018.1
    UniProtKB/Swiss-Prot
    Q61512, Q99JW5
    Related
    ENSMUSP00000061935.9, ENSMUST00000053577.9
    Conserved Domains (1) summary
    cd00191
    Location:65125
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    87943407..87958555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)