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Idh3b isocitrate dehydrogenase 3 (NAD+) beta [ Mus musculus (house mouse) ]

Gene ID: 170718, updated on 2-Nov-2024

Summary

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Official Symbol
Idh3bprovided by MGI
Official Full Name
isocitrate dehydrogenase 3 (NAD+) betaprovided by MGI
Primary source
MGI:MGI:2158650
See related
Ensembl:ENSMUSG00000027406 AllianceGenome:MGI:2158650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable NAD binding activity; magnesium ion binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Located in mitochondrion. Part of isocitrate dehydrogenase complex (NAD+). Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 305.9), kidney adult (RPKM 164.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Idh3b in Genome Data Viewer
Location:
2 F1; 2 63.2 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130121229..130126371, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130279309..130284451, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NOP56 ribonucleoprotein Neighboring gene STARR-positive B cell enhancer ABC_E3405 Neighboring gene predicted gene, 23650 Neighboring gene small nucleolar RNA, C/D box 57 Neighboring gene STARR-seq mESC enhancer starr_05691 Neighboring gene early B cell factor 4 Neighboring gene predicted gene, 39936 Neighboring gene ribosomal protein L27A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability. Zhu S, et al. J Biol Chem, 2022 Sep. PMID 35985423, Free PMC Article
  2. Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function. Findlay AS, et al. Dis Model Mech, 2018 Dec 18. PMID 30478029, Free PMC Article
  3. A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology. Wang X, et al. Signal Transduct Target Ther, 2024 Apr 29. PMID 38679634, Free PMC Article
  4. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, et al. J Biol Chem, 2003 Dec 26. PMID 14555658
  5. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A positive feedback inhibition of isocitrate dehydrogenase 3beta on paired-box gene 6 promotes Alzheimer-like pathology.
    Title: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology.
  2. Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability.
    Title: Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of isocitrate dehydrogenase complex (NAD+) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of isocitrate dehydrogenase complex (NAD+) ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Names
N14A tumor-related protein
isocitrate dehydrogenase 3 beta
NP_001349681.1
NP_570954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362752.1 → NP_001349681.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL833804
    UniProtKB/TrEMBL
    A0A668KL51
    Related
    ENSMUSP00000159209.2, ENSMUST00000239288.2
    Conserved Domains (1) summary
    cl00445
    Location:46 → 376
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase

  2. NM_130884.4 → NP_570954.1  isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_570954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL833804, AW049896, BY336999, CN456483, DN176034
    Consensus CDS
    CCDS16738.1
    UniProtKB/TrEMBL
    Q91VA7
    Related
    ENSMUSP00000028892.5, ENSMUST00000028892.11
    Conserved Domains (1) summary
    cl00445
    Location:46 → 379
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130121229..130126371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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