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NUDT10 nudix hydrolase 10 [ Homo sapiens (human) ]

Gene ID: 170685, updated on 23-Nov-2021

Summary

Official Symbol
NUDT10provided by HGNC
Official Full Name
nudix hydrolase 10provided by HGNC
Primary source
HGNC:HGNC:17621
See related
Ensembl:ENSG00000122824 MIM:300527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APS2; DIPP3a; DIPP3-alpha
Summary
This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]
Expression
Biased expression in testis (RPKM 20.6), brain (RPKM 8.6) and 6 other tissues See more
Orthologs
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Genomic context

See NUDT10 in Genome Data Viewer
Location:
Xp11.22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (51332231..51337525)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (51075083..51080377)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene acyl-coenzyme A synthetase ACSM6, mitochondrial-like Neighboring gene long intergenic non-protein coding RNA 1284 Neighboring gene MAGE family member A10 pseudogene Neighboring gene uncharacterized LOC105373204 Neighboring gene centromere protein V pseudogene Neighboring gene EZH inhibitory protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
GeneReviews: Not available
Multiple newly identified loci associated with prostate cancer susceptibility.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bis(5'-adenosyl)-hexaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bis(5'-adenosyl)-pentaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diphosphoinositol-polyphosphate diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diphosphoinositol-polyphosphate diphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables endopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol diphosphate pentakisphosphate diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol diphosphate tetrakisphosphate diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diadenosine hexaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diadenosine pentaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diphosphoinositol polyphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
diphosphoinositol polyphosphate phosphohydrolase 3-alpha
Names
diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha
diadenosine hexaphosphate hydrolase (AMP-forming)
nucleoside diphosphate-linked moiety X motif 10
nudix (nucleoside diphosphate linked moiety X)-type motif 10
nudix motif 10
NP_001291892.1
NP_694853.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304963.2NP_001291892.1  diphosphoinositol polyphosphate phosphohydrolase 3-alpha

    See identical proteins and their annotated locations for NP_001291892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC049383, BC050700, BX449265, CN399689
    Consensus CDS
    CCDS35278.1
    UniProtKB/Swiss-Prot
    Q8NFP7
    Related
    ENSP00000348831.2, ENST00000356450.3
    Conserved Domains (1) summary
    cd04666
    Location:18137
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
  2. NM_153183.4NP_694853.1  diphosphoinositol polyphosphate phosphohydrolase 3-alpha

    See identical proteins and their annotated locations for NP_694853.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC233976, AF469196, AK291952
    Consensus CDS
    CCDS35278.1
    UniProtKB/Swiss-Prot
    Q8NFP7
    Related
    ENSP00000365174.3, ENST00000376006.7
    Conserved Domains (1) summary
    cd04666
    Location:18137
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    51332231..51337525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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