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XAGE3 X antigen family member 3 [ Homo sapiens (human) ]

Gene ID: 170626, updated on 13-Mar-2020

Summary

Official Symbol
XAGE3provided by HGNC
Official Full Name
X antigen family member 3provided by HGNC
Primary source
HGNC:HGNC:14618
See related
Ensembl:ENSG00000171402 MIM:300740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLAC6; GAGED4; XAGE-3; pp9012; CT12.3a; CT12.3b
Summary
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward placenta (RPKM 81.9) See more
Orthologs

Genomic context

See XAGE3 in Genome Data Viewer
Location:
Xp11.22
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (52862528..52868140, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52891557..52897119, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X antigen family member 3-like Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 4 Neighboring gene family with sequence similarity 156 member B Neighboring gene family with sequence similarity 156 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
X antigen family member 3
Names
CT12.3
G antigen, family D, 4
cancer/testis antigen 12.3
cancer/testis antigen family 12, member 3a
cancer/testis antigen family 12, member 3b
g antigen family D member 4
placenta-specific 6
placenta-specific gene 6 protein
protein XAGE-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130776.1NP_570132.1  X antigen family member 3

    See identical proteins and their annotated locations for NP_570132.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon 1, as compared to variant 1. It thus has a different and shorter 5' UTR, but encodes the same protein as variant 1.
    Source sequence(s)
    AJ318881
    Consensus CDS
    CCDS14347.1
    UniProtKB/Swiss-Prot
    Q8WTP9
    Related
    ENSP00000364640.3, ENST00000375491.7
    Conserved Domains (1) summary
    pfam05831
    Location:1105
    GAGE; GAGE protein
  2. NM_133179.3NP_573440.1  X antigen family member 3

    See identical proteins and their annotated locations for NP_573440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate exon 1, as compared to variant 2. It thus has a different and longer 5' UTR, but encodes the same protein as variant 2.
    Source sequence(s)
    AF318372, BC062680
    Consensus CDS
    CCDS14347.1
    UniProtKB/Swiss-Prot
    Q8WTP9
    Related
    ENSP00000303061.3, ENST00000346279.4
    Conserved Domains (1) summary
    pfam05831
    Location:1105
    GAGE; GAGE protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    52862528..52868140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530768.2XP_011529070.1  X antigen family member 3 isoform X1

    See identical proteins and their annotated locations for XP_011529070.1

    UniProtKB/Swiss-Prot
    Q8WTP9
    Conserved Domains (1) summary
    pfam05831
    Location:1105
    GAGE; GAGE protein
  2. XM_011530769.2XP_011529071.1  X antigen family member 3 isoform X1

    See identical proteins and their annotated locations for XP_011529071.1

    UniProtKB/Swiss-Prot
    Q8WTP9
    Conserved Domains (1) summary
    pfam05831
    Location:1105
    GAGE; GAGE protein
  3. XM_011530770.2XP_011529072.1  X antigen family member 3 isoform X1

    See identical proteins and their annotated locations for XP_011529072.1

    UniProtKB/Swiss-Prot
    Q8WTP9
    Conserved Domains (1) summary
    pfam05831
    Location:1105
    GAGE; GAGE protein
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