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S100Z S100 calcium binding protein Z [ Homo sapiens (human) ]

Gene ID: 170591, updated on 14-Aug-2021

Summary

Official Symbol
S100Zprovided by HGNC
Official Full Name
S100 calcium binding protein Zprovided by HGNC
Primary source
HGNC:HGNC:30367
See related
Ensembl:ENSG00000171643 MIM:610103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gm625; S100-zeta
Summary
Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See S100Z in Genome Data Viewer
Location:
5q13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (76849953..76952882)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76145839..76217475)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene F2R like trypsin receptor 1 Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene RNA, U6atac small nuclear 36, pseudogene Neighboring gene corticotropin releasing hormone binding protein Neighboring gene angiogenic factor with G-patch and FHA domains 1 Neighboring gene zinc finger BED-type containing 3 Neighboring gene small nucleolar RNA, H/ACA box 47

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 

General protein information

Preferred Names
protein S100-Z
Names
S100 calcium binding protein, zeta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130772.4NP_570128.2  protein S100-Z

    See identical proteins and their annotated locations for NP_570128.2

    Status: VALIDATED

    Source sequence(s)
    AC027342, AF437876, BC022320, BX281742, CD368348
    Consensus CDS
    CCDS43333.1
    UniProtKB/Swiss-Prot
    Q8WXG8
    Related
    ENSP00000320430.4, ENST00000317593.9
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    76849953..76952882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543241.2XP_011541543.1  protein S100-Z isoform X1

    See identical proteins and their annotated locations for XP_011541543.1

    UniProtKB/Swiss-Prot
    Q8WXG8
    Related
    ENSP00000426768.1, ENST00000513010.5
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_011543240.3XP_011541542.1  protein S100-Z isoform X1

    See identical proteins and their annotated locations for XP_011541542.1

    UniProtKB/Swiss-Prot
    Q8WXG8
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. XM_017009173.1XP_016864662.1  protein S100-Z isoform X1

    UniProtKB/Swiss-Prot
    Q8WXG8
    Related
    ENSP00000483535.1, ENST00000613039.1
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. XM_011543239.2XP_011541541.1  protein S100-Z isoform X1

    See identical proteins and their annotated locations for XP_011541541.1

    UniProtKB/Swiss-Prot
    Q8WXG8
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. XM_011543244.2XP_011541546.1  protein S100-Z isoform X1

    See identical proteins and their annotated locations for XP_011541546.1

    UniProtKB/Swiss-Prot
    Q8WXG8
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  6. XM_017009172.1XP_016864661.1  protein S100-Z isoform X1

    UniProtKB/Swiss-Prot
    Q8WXG8
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  7. XM_017009171.1XP_016864660.1  protein S100-Z isoform X1

    UniProtKB/Swiss-Prot
    Q8WXG8
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  8. XM_011543245.2XP_011541547.1  protein S100-Z isoform X1

    See identical proteins and their annotated locations for XP_011541547.1

    UniProtKB/Swiss-Prot
    Q8WXG8
    Conserved Domains (1) summary
    cl08302
    Location:193
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
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