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Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) [ Mus musculus (house mouse) ]

Gene ID: 170439, updated on 8-Nov-2022

Summary

Official Symbol
Elovl6provided by MGI
Official Full Name
ELOVL family member 6, elongation of long chain fatty acids (yeast)provided by MGI
Primary source
MGI:MGI:2156528
See related
Ensembl:ENSMUSG00000041220 AllianceGenome:MGI:2156528
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FAE; LCE
Summary
Enables acyltransferase activity, transferring groups other than amino-acyl groups. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within fatty acid elongation. Is integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ELOVL6 (ELOVL fatty acid elongase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 61.4), subcutaneous fat pad adult (RPKM 39.1) and 25 other tissues See more
Orthologs
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Genomic context

See Elovl6 in Genome Data Viewer
Location:
3; 3 G3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129326035..129432144)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129532386..129638495)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene POU domain, class 5, transcription factor 1, related sequence 4 Neighboring gene ribosomal protein L7A, pseudogene 7 Neighboring gene predicted gene, 35986 Neighboring gene epidermal growth factor Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene predicted gene, 36130

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC107467

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid elongase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables very-long-chain 3-ketoacyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of fatty acid elongase complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
elongation of very long chain fatty acids protein 6
Names
3-keto acyl-CoA synthase Elovl6
ELOVL FA elongase 6
ELOVL fatty acid elongase 6
fatty acyl-CoA elongase
long chain fatty acid elongase
long chain fatty acyl elongase
myelin-associated SUR4 protein
very long chain 3-ketoacyl-CoA synthase 6
very long chain 3-oxoacyl-CoA synthase 6
NP_569717.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130450.2NP_569717.1  elongation of very long chain fatty acids protein 6

    See identical proteins and their annotated locations for NP_569717.1

    Status: PROVISIONAL

    Source sequence(s)
    AC098732, AK029029
    Consensus CDS
    CCDS38632.1
    UniProtKB/Swiss-Prot
    Q8CE45, Q920L5
    Related
    ENSMUSP00000071351.3, ENSMUST00000071402.7
    Conserved Domains (1) summary
    pfam01151
    Location:25264
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    129326035..129432144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)