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SPIN3 spindlin family member 3 [ Homo sapiens (human) ]

Gene ID: 169981, updated on 13-Mar-2020

Summary

Official Symbol
SPIN3provided by HGNC
Official Full Name
spindlin family member 3provided by HGNC
Primary source
HGNC:HGNC:27272
See related
Ensembl:ENSG00000204271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPIN-3; TDRD27; bA445O16.1
Expression
Ubiquitous expression in brain (RPKM 4.7), prostate (RPKM 3.7) and 24 other tissues See more
Orthologs

Genomic context

See SPIN3 in Genome Data Viewer
Location:
Xp11.21
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (56975120..56995801, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (57002803..57021988, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ubiquilin 2 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 1 Neighboring gene negative regulator of P-body association Neighboring gene SPIN2 family pseudogene 1 Neighboring gene spindlin family member 2B Neighboring gene fatty acid amide hydrolase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41127, FLJ54952, MGC40395

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
gamete generation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
spindlin-3
Names
bA445O16.1 (DXF34)
spindlin-like protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010862.3NP_001010862.2  spindlin-3

    See identical proteins and their annotated locations for NP_001010862.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AJ271379, AL139397, BX403408, DB151976
    Consensus CDS
    CCDS43963.1
    UniProtKB/Swiss-Prot
    Q5JUX0
    Related
    ENSP00000364054.3, ENST00000374919.6
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family

RNA

  1. NR_027139.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes three alternate exons at its 3' end, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL139397, BC032490, DB151976
    Related
    ENST00000640131.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    56975120..56995801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029315.1XP_016884804.1  spindlin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q5JUX0
    Related
    ENSP00000492795.1, ENST00000638257.1
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  2. XM_006724577.3XP_006724640.1  spindlin-3 isoform X1

    See identical proteins and their annotated locations for XP_006724640.1

    UniProtKB/Swiss-Prot
    Q5JUX0
    Related
    ENSP00000491624.1, ENST00000638386.1
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
  3. XM_006724578.3XP_006724641.1  spindlin-3 isoform X1

    See identical proteins and their annotated locations for XP_006724641.1

    UniProtKB/Swiss-Prot
    Q5JUX0
    Related
    ENSP00000492381.1, ENST00000639007.1
    Conserved Domains (1) summary
    pfam02513
    Location:5098
    Spin-Ssty; Spin/Ssty Family
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