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Lig1 ligase I, DNA, ATP-dependent [ Mus musculus (house mouse) ]

Gene ID: 16881, updated on 2-Nov-2024

Summary

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Official Symbol
Lig1provided by MGI
Official Full Name
ligase I, DNA, ATP-dependentprovided by MGI
Primary source
MGI:MGI:101789
See related
Ensembl:ENSMUSG00000056394 AllianceGenome:MGI:101789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LigI
Summary
Predicted to enable DNA ligase (ATP) activity. Acts upstream of or within DNA replication; double-strand break repair via nonhomologous end joining; and response to hydrogen peroxide. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 34.7), liver E14.5 (RPKM 31.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Lig1 in Genome Data Viewer
Location:
7 A1; 7 7.82 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13011101..13045351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13277175..13311426)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 89 Neighboring gene STARR-seq mESC enhancer starr_18077 Neighboring gene vomeronasal 1 receptor, pseudogene 69 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene STARR-positive B cell enhancer ABC_E4896 Neighboring gene STARR-seq mESC enhancer starr_18078 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent) Neighboring gene ribosomal protein S8, pseudogene 4 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent), pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparison between cDNA clones encoding murine DNA ligase I. Jessop JK, et al. Gene, 1995 Jul 28. PMID 7642116
  2. Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme. Savini E, et al. Gene, 1994 Jul 8. PMID 8039710
  3. Efficient BLG-Cre mediated gene deletion in the mammary gland. Selbert S, et al. Transgenic Res, 1998 Sep. PMID 9859227
  4. Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene. Harrison C, et al. Cancer Res, 2002 Jul 15. PMID 12124343
  5. DNA ligase I is not essential for mammalian cell viability. Han L, et al. Cell Rep, 2014 Apr 24. PMID 24726358, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
    Title: Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
  2. Increased presynaptic glutamate release is a key early event resulting from Lgi1-deficiency, which likely contributes to epileptogenesis.
    Title: LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development.
  3. Lig1 is not absolutely required for cellular DNA replication and repair in Lig1-null cell line.
    Title: DNA ligase I is not essential for mammalian cell viability.
  4. LigI has a highly specific role in CTG repeat maintenance in the maternal germline, involved in mediating CTG expansions and in the avoidance of maternal CTG contractions.
    Title: Maternal germline-specific effect of DNA ligase I on CTG/CAG instability.
  5. DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
    Title: DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA ligase (ATP) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA ligase (ATP) activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA ligation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
NOT acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Okazaki fragment processing involved in mitotic DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lagging strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA ligase 1
Names
DNA ligase I
polydeoxyribonucleotide synthase [ATP] 1
NP_001076657.2
NP_001186239.2
NP_034845.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083188.2 → NP_001076657.2  DNA ligase 1

    Status: VALIDATED

    Source sequence(s)
    AC161792, AK161793, MG954305
    UniProtKB/Swiss-Prot
    P37913
    UniProtKB/TrEMBL
    Q8R055
    Related
    ENSMUSP00000126525.4, ENSMUST00000165964.10
    Conserved Domains (1) summary
    PLN03113
    Location:171 → 912
    PLN03113; DNA ligase 1; Provisional

  2. NM_001199310.2 → NP_001186239.2  DNA ligase 1

    Status: VALIDATED

    Source sequence(s)
    AC161792, AK161793, MG954305
    UniProtKB/Swiss-Prot
    P37913
    UniProtKB/TrEMBL
    Q8R055
    Related
    ENSMUSP00000136972.4, ENSMUST00000177588.10
    Conserved Domains (1) summary
    PLN03113
    Location:171 → 912
    PLN03113; DNA ligase 1; Provisional

  3. NM_010715.3 → NP_034845.3  DNA ligase 1

    Status: VALIDATED

    Source sequence(s)
    AC161792, AK161793, MG954305
    UniProtKB/Swiss-Prot
    P37913
    UniProtKB/TrEMBL
    Q8R055
    Related
    ENSMUSP00000096411.7, ENSMUST00000098814.13
    Conserved Domains (1) summary
    PLN03113
    Location:171 → 912
    PLN03113; DNA ligase 1; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    13011101..13045351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37913.2 GenPept UniProtKB/Swiss-Prot:P37913

Gene LinkOut

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