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Lgals9 lectin, galactose binding, soluble 9 [ Mus musculus (house mouse) ]

Gene ID: 16859, updated on 23-Nov-2021

Summary

Official Symbol
Lgals9provided by MGI
Official Full Name
lectin, galactose binding, soluble 9provided by MGI
Primary source
MGI:MGI:109496
See related
Ensembl:ENSMUSG00000001123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gal-9; Lgals5; LGALS35; AA407335; AI194909; AI265545; galectin-9
Expression
Broad expression in liver adult (RPKM 359.2), large intestine adult (RPKM 344.6) and 18 other tissues See more
Orthologs
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Genomic context

See Lgals9 in Genome Data Viewer
Location:
11; 11 B5
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78853805..78875750, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78962979..78984924, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (78776481..78798426, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19741 Neighboring gene Nos2 promoter region Neighboring gene nitric oxide synthase 2, inducible Neighboring gene predicted gene 11201 Neighboring gene kinase suppressor of ras 1 Neighboring gene predicted gene, 30413

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables carbohydrate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables disaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables galactoside binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables galactoside binding ISA
Inferred from Sequence Alignment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISA
Inferred from Sequence Alignment
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of protein location IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interferon-gamma production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of natural killer cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of T cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of T-helper 17 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
galectin-9
Names
lectin, galactose binding, soluble 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159301.1NP_001152773.1  galectin-9 isoform 2

    See identical proteins and their annotated locations for NP_001152773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK146044, CA546274
    Consensus CDS
    CCDS48858.1
    UniProtKB/Swiss-Prot
    O08573
    Related
    ENSMUSP00000103903.4, ENSMUST00000108268.10
    Conserved Domains (2) summary
    smart00908
    Location:199321
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16145
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
  2. NM_010708.2NP_034838.2  galectin-9 isoform 1

    See identical proteins and their annotated locations for NP_034838.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146044, CA458877, CA546274
    Consensus CDS
    CCDS25116.1
    UniProtKB/Swiss-Prot
    O08573
    UniProtKB/TrEMBL
    G3X9T7
    Related
    ENSMUSP00000103904.4, ENSMUST00000108269.10
    Conserved Domains (2) summary
    smart00908
    Location:230352
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16145
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78853805..78875750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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