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Lep leptin [ Mus musculus (house mouse) ]

Gene ID: 16846, updated on 7-Feb-2023

Summary

Official Symbol
Lepprovided by MGI
Official Full Name
leptinprovided by MGI
Primary source
MGI:MGI:104663
See related
Ensembl:ENSMUSG00000059201 AllianceGenome:MGI:104663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ob; obese
Summary
Enables DNA binding activity and growth factor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including insulin secretion; monocarboxylic acid metabolic process; and regulation of insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 267.7), genital fat pad adult (RPKM 183.5) and 1 other tissue See more
Orthologs
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Genomic context

See Lep in Genome Data Viewer
Location:
6 A3.3; 6 12.3 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29060220..29073875)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29060221..29073876)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567373 Neighboring gene microRNA 129-1 Neighboring gene long noncoding RNA upstream of leptin Neighboring gene Lep proximal promoter region Neighboring gene predicted gene, 25589 Neighboring gene RNA binding motif protein 28

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IDA
Inferred from Direct Assay
more info
 
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables leptin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of protein kinase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adipose tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adult feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bile acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bone growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within eating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within elastin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy reserve metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid beta-oxidation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in leptin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of appetite IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of appetite by leptin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of appetite by leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucagon secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glutamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in ovulation from ovarian follicle ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
 
involved_in positive regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of intestinal cholesterol absorption IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of lipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of lipoprotein lipid oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of steroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to dietary excess IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to dietary excess ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sexual reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sexual reproduction ISO
Inferred from Sequence Orthology
more info
 
involved_in tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leptin
Names
obesity factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008493.3NP_032519.1  leptin precursor

    See identical proteins and their annotated locations for NP_032519.1

    Status: VALIDATED

    Source sequence(s)
    AK030984
    Consensus CDS
    CCDS19955.1
    UniProtKB/Swiss-Prot
    P41160
    UniProtKB/TrEMBL
    Q544U0
    Related
    ENSMUSP00000067046.6, ENSMUST00000069789.12
    Conserved Domains (1) summary
    pfam02024
    Location:26167
    Leptin; Leptin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29060220..29073875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)