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Lep leptin [ Mus musculus (house mouse) ]

Gene ID: 16846, updated on 14-May-2019

Summary

Official Symbol
Lepprovided by MGI
Official Full Name
leptinprovided by MGI
Primary source
MGI:MGI:104663
See related
Ensembl:ENSMUSG00000059201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ob; obese
Expression
Biased expression in subcutaneous fat pad adult (RPKM 267.7), genital fat pad adult (RPKM 183.5) and 1 other tissue See more
Orthologs

Genomic context

See Lep in Genome Data Viewer
Location:
6 A3.3; 6 12.3 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (29060195..29073877)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29010221..29023876)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene microRNA 129-1 Neighboring gene long noncoding RNA upstream of leptin Neighboring gene RNA binding motif protein 28 Neighboring gene proline-rich transmembrane protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
growth factor activity IDA
Inferred from Direct Assay
more info
 
hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hormone activity ISO
Inferred from Sequence Orthology
more info
 
peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
adipose tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
adult feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
bile acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
bone growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
 
central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
eating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
elastin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
energy reserve metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation IGI
Inferred from Genetic Interaction
more info
PubMed 
fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
 
interleukin-8 secretion ISO
Inferred from Sequence Orthology
more info
 
intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
leptin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of appetite IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of appetite by leptin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of appetite by leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cartilage development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucagon secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glutamine transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
ovulation from ovarian follicle ISO
Inferred from Sequence Orthology
more info
 
phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
placenta development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JAK-STAT cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myeloid cell differentiation IDA
Inferred from Direct Assay
more info
 
positive regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intestinal cholesterol absorption IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of lipoprotein lipid oxidation ISO
Inferred from Sequence Orthology
more info
 
regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of steroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to dietary excess IGI
Inferred from Genetic Interaction
more info
PubMed 
response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to dietary excess ISO
Inferred from Sequence Orthology
more info
 
response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
sexual reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
sexual reproduction ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leptin
Names
obesity factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008493.3NP_032519.1  leptin precursor

    See identical proteins and their annotated locations for NP_032519.1

    Status: VALIDATED

    Source sequence(s)
    AK030984
    Consensus CDS
    CCDS19955.1
    UniProtKB/Swiss-Prot
    P41160
    UniProtKB/TrEMBL
    Q544U0
    Related
    ENSMUSP00000067046.5, ENSMUST00000069789.11
    Conserved Domains (1) summary
    pfam02024
    Location:26167
    Leptin; Leptin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    29060195..29073877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504999.1XP_006505062.1  leptin isoform X1

    See identical proteins and their annotated locations for XP_006505062.1

    Conserved Domains (1) summary
    pfam02024
    Location:26166
    Leptin; Leptin
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