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Lef1 lymphoid enhancer binding factor 1 [ Mus musculus (house mouse) ]

Gene ID: 16842, updated on 27-Feb-2024

Summary

Official Symbol
Lef1provided by MGI
Official Full Name
lymphoid enhancer binding factor 1provided by MGI
Primary source
MGI:MGI:96770
See related
Ensembl:ENSMUSG00000027985 AllianceGenome:MGI:96770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lef-1; 3000002B05
Summary
Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of gamma-delta T cell differentiation; and secondary palate development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 63.3), spleen adult (RPKM 14.2) and 8 other tissues See more
Orthologs
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Genomic context

See Lef1 in Genome Data Viewer
Location:
3 G3; 3 60.78 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (130903972..131018006)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (131110297..131224357)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:130639948-130640160 Neighboring gene enolase 1, alpha non-neuron pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:130722148-130722331 Neighboring gene STARR-positive B cell enhancer ABC_E3469 Neighboring gene STARR-seq mESC enhancer starr_08992 Neighboring gene STARR-seq mESC enhancer starr_08993 Neighboring gene STARR-seq mESC enhancer starr_08994 Neighboring gene STARR-seq mESC enhancer starr_08995 Neighboring gene STARR-positive B cell enhancer ABC_E6127 Neighboring gene predicted gene, 36603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:130860450-130860637 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:130911499-130911865 Neighboring gene STARR-positive B cell enhancer ABC_E6128 Neighboring gene hydroxyacyl-Coenzyme A dehydrogenase Neighboring gene TatD DNase domain containing 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding, bending EXP
Inferred from Experiment
more info
PubMed 
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell receptor V(D)J recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T-helper 1 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within alpha-beta T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anatomical structure regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chorio-allantoic fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within face morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain neuroblast division IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain radial glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within formation of radial glial scaffolds IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process in bone marrow cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in odontoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell proliferation in bone marrow ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of odontoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of taste IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tongue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trachea gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lymphoid enhancer-binding factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276402.2NP_001263331.1  lymphoid enhancer-binding factor 1 isoform b

    See identical proteins and their annotated locations for NP_001263331.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the internal coding region and lacks an exon in the 3' coding region which results in the use of a downstream stop codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC114668, AC123634
    Consensus CDS
    CCDS71319.1
    UniProtKB/TrEMBL
    Q8BGZ9
    Related
    ENSMUSP00000101948.3, ENSMUST00000106341.9
    Conserved Domains (2) summary
    cd01388
    Location:268339
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1211
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. NM_001276403.1NP_001263332.1  lymphoid enhancer-binding factor 1 isoform c

    See identical proteins and their annotated locations for NP_001263332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC114668, AK028246, AK083328, BE632124
    Consensus CDS
    CCDS71320.1
    UniProtKB/TrEMBL
    Q8C402
    Related
    ENSMUSP00000096211.4, ENSMUST00000098611.4
    Conserved Domains (2) summary
    cd01388
    Location:230301
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1145
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. NM_001379059.1NP_001365988.1  lymphoid enhancer-binding factor 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC114668, AC123634
    Conserved Domains (2) summary
    cd01388
    Location:296367
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1211
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. NM_001379060.1NP_001365989.1  lymphoid enhancer-binding factor 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC114668, AC123634
    UniProtKB/TrEMBL
    D3Z654
    Related
    ENSMUSP00000067808.7, ENSMUST00000066849.13
    Conserved Domains (2) summary
    cd01388
    Location:268339
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1211
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. NM_001379061.1NP_001365990.1  lymphoid enhancer-binding factor 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC114668, AC123634
    Conserved Domains (2) summary
    cd01388
    Location:202273
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:2145
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. NM_001379062.1NP_001365991.1  lymphoid enhancer-binding factor 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC123634
    Conserved Domains (2) summary
    cd01388
    Location:115186
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:130
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. NM_010703.5NP_034833.2  lymphoid enhancer-binding factor 1 isoform a

    See identical proteins and their annotated locations for NP_034833.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC114668, AC123634
    Consensus CDS
    CCDS17842.1
    UniProtKB/Swiss-Prot
    P27782
    UniProtKB/TrEMBL
    Q3TYB0
    Related
    ENSMUSP00000029611.8, ENSMUST00000029611.14
    Conserved Domains (2) summary
    cd01388
    Location:296367
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1211
    CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    130903972..131018006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252440.2XP_030108300.1  lymphoid enhancer-binding factor 1 isoform X2

    Conserved Domains (2) summary
    cd01388
    Location:202273
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:2145
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. XM_006501070.4XP_006501133.1  lymphoid enhancer-binding factor 1 isoform X1

    Conserved Domains (2) summary
    cd01388
    Location:230301
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:2145
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. XM_036162910.1XP_036018803.1  lymphoid enhancer-binding factor 1 isoform X3

    Conserved Domains (2) summary
    cd01388
    Location:87158
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:130
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. XM_036162911.1XP_036018804.1  lymphoid enhancer-binding factor 1 isoform X4

    Conserved Domains (2) summary
    cd01388
    Location:115186
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:130
    CTNNB1_binding; N-terminal CTNNB1 binding