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DACT2 dishevelled binding antagonist of beta catenin 2 [ Homo sapiens (human) ]

Gene ID: 168002, updated on 1-Jun-2020

Summary

Official Symbol
DACT2provided by HGNC
Official Full Name
dishevelled binding antagonist of beta catenin 2provided by HGNC
Primary source
HGNC:HGNC:21231
See related
Ensembl:ENSG00000164488 MIM:608966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPR2; DAPPER2; C6orf116; bA503C24.7
Expression
Biased expression in placenta (RPKM 6.6), prostate (RPKM 2.5) and 8 other tissues See more
Orthologs

Genomic context

See DACT2 in Genome Data Viewer
Location:
6q27
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (168292830..168319777, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (168693510..168720459, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929420 Neighboring gene CTAGE family member 13, pseudogene Neighboring gene uncharacterized LOC105378138 Neighboring gene uncharacterized LOC105378139 Neighboring gene uncharacterized LOC107986549

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31232, MGC133141, MGC133142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
delta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase A binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
epithelial cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
inner medullary collecting duct development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of nodal signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of nodal signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
skin development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dapper homolog 2
Names
dapper antagonist of catenin 2
dapper homolog 2, antagonist of beta-catenin
dapper, antagonist of beta-catenin, homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286350.2NP_001273279.1  dapper homolog 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AF318336, AL606970, BC092498, BC111790, BX377941
    Consensus CDS
    CCDS75554.1
    UniProtKB/Swiss-Prot
    Q5SW24
    Related
    ENSP00000476573.1, ENST00000610183.1
    Conserved Domains (1) summary
    pfam15268
    Location:45604
    Dapper; Dapper
  2. NM_001286351.2NP_001273280.1  dapper homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 3' exon structure and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AF318336, AL606970, BC092498, BC111790
    Consensus CDS
    CCDS69241.1
    UniProtKB/Swiss-Prot
    Q5SW24
    Related
    ENSP00000355761.2, ENST00000366796.7
    Conserved Domains (1) summary
    pfam15268
    Location:26181
    Dapper; Dapper
  3. NM_214462.5NP_999627.2  dapper homolog 2 isoform a

    See identical proteins and their annotated locations for NP_999627.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF318336, AL606970, BC092498, BC111790, BX377941
    Consensus CDS
    CCDS47519.1
    UniProtKB/Swiss-Prot
    Q5SW24
    Related
    ENSP00000355760.3, ENST00000366795.4
    Conserved Domains (1) summary
    pfam15268
    Location:26774
    Dapper; Dapper

RNA

  1. NR_104425.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two internal exons and uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AF318336, AL606970, BC092498, BC111764, BX377941
    Related
    ENST00000607983.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    168292830..168319777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535507.2XP_011533809.1  dapper homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011533809.1

    Conserved Domains (1) summary
    pfam15268
    Location:1644
    Dapper; Dapper
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