U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mafb MAF bZIP transcription factor B [ Mus musculus (house mouse) ]

Gene ID: 16658, updated on 18-Apr-2024

Summary

Official Symbol
Mafbprovided by MGI
Official Full Name
MAF bZIP transcription factor Bprovided by MGI
Primary source
MGI:MGI:104555
See related
Ensembl:ENSMUSG00000074622 AllianceGenome:MGI:104555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kr; Krml; Krml1; Kreisler
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in abducens nerve formation; negative regulation of osteoclast differentiation; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and respiratory gaseous exchange by respiratory system. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Used to study Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Human ortholog(s) of this gene implicated in Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
2 H2; 2 80.92 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (160205597..160208985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (160363677..160367065, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34741 Neighboring gene predicted gene, 34805 Neighboring gene VISTA enhancer mm645 Neighboring gene predicted gene 826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:160153541-160153763 Neighboring gene predicted gene, 34980 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:160253255-160253456 Neighboring gene STARR-seq mESC enhancer starr_06256 Neighboring gene STARR-seq mESC enhancer starr_06258 Neighboring gene STARR-seq mESC enhancer starr_06259 Neighboring gene predicted gene 14221

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in abducens nerve formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain segmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cornified envelope assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhombomere 5 development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhombomere 6 development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within segment specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor MafB
Names
Kreisler (maf-related) leucine zipper protein
V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
maf-B
segmentation protein Kr
transcription factor Maf-1
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010658.3NP_034788.1  transcription factor MafB

    See identical proteins and their annotated locations for NP_034788.1

    Status: VALIDATED

    Source sequence(s)
    AK132425, AL591665
    Consensus CDS
    CCDS16994.1
    UniProtKB/Swiss-Prot
    P54841, Q3U3C8, Q3UPT9
    Related
    ENSMUSP00000096728.4, ENSMUST00000099126.5
    Conserved Domains (2) summary
    cd14718
    Location:233302
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:80113
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    160205597..160208985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)