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Sspn sarcospan [ Mus musculus (house mouse) ]

Gene ID: 16651, updated on 1-Mar-2024

Summary

Official Symbol
Sspnprovided by MGI
Official Full Name
sarcospanprovided by MGI
Primary source
MGI:MGI:1353511
See related
Ensembl:ENSMUSG00000030255 AllianceGenome:MGI:1353511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Krag; Gm32675
Summary
Located in sarcolemma. Is expressed in early conceptus; secondary oocyte; and skin. Orthologous to human SSPN (sarcospan). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 26.2), bladder adult (RPKM 15.9) and 13 other tissues See more
Orthologs
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Genomic context

See Sspn in Genome Data Viewer
Location:
6 G3; 6 77.7 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145860423..145910951)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145931873..145965225)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38927 Neighboring gene VISTA enhancer mm1548 Neighboring gene basic helix-loop-helix family, member e41 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145832170-145832470 Neighboring gene STARR-positive B cell enhancer ABC_E10420 Neighboring gene STARR-seq mESC enhancer starr_17793 Neighboring gene predicted gene, 32838 Neighboring gene predicted gene, 38928 Neighboring gene predicted gene, 32914

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of dystrophin-associated glycoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sarcospan
Names
K-ras oncogene-associated protein
Kras oncogene-associated
kirsten-Ras-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310837.1NP_001297766.1  sarcospan isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC144936, AK164529, CA558278, CF915662, CK333705
    Consensus CDS
    CCDS80637.1
    UniProtKB/TrEMBL
    E9Q8Y7
    Related
    ENSMUSP00000107331.2, ENSMUST00000111702.8
    Conserved Domains (1) summary
    pfam04103
    Location:9107
    CD20; CD20-like family
  2. NM_010656.3NP_034786.1  sarcospan isoform 1

    See identical proteins and their annotated locations for NP_034786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC144936
    Consensus CDS
    CCDS20698.1
    UniProtKB/Swiss-Prot
    Q60594, Q62147
    UniProtKB/TrEMBL
    Q3TPB3, Q3TRE0
    Related
    ENSMUSP00000032383.8, ENSMUST00000032383.14
    Conserved Domains (1) summary
    pfam04103
    Location:37183
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    145860423..145910951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165893.1XP_036021786.1  sarcospan isoform X2

    UniProtKB/TrEMBL
    E9Q8Y7
    Conserved Domains (1) summary
    pfam04103
    Location:9107
    CD20; CD20-like family
  2. XM_006506916.5XP_006506979.1  sarcospan isoform X1

    Conserved Domains (1) summary
    pfam04103
    Location:4120
    CD20; CD20-like family