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Fabp5 fatty acid binding protein 5, epidermal [ Mus musculus (house mouse) ]

Gene ID: 16592, updated on 10-Mar-2024

Summary

Official Symbol
Fabp5provided by MGI
Official Full Name
fatty acid binding protein 5, epidermalprovided by MGI
Primary source
MGI:MGI:101790
See related
Ensembl:ENSMUSG00000027533 AllianceGenome:MGI:101790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klbp; mal1; Fabpe; E-FABP; PA-FABP
Summary
The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]
Expression
Biased expression in liver E18 (RPKM 937.5), liver E14 (RPKM 371.8) and 7 other tissues See more
Orthologs
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Genomic context

See Fabp5 in Genome Data Viewer
Location:
3 A1; 3 2.47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10077645..10081670)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10012585..10016610)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene Neighboring gene STARR-seq mESC enhancer starr_06932 Neighboring gene STARR-seq mESC enhancer starr_06933 Neighboring gene EST AA881470 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06934 Neighboring gene predicted gene, 33365 Neighboring gene myelin expression factor 2 like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fatty acid-binding protein 5; uncharacterized protein LOC16592
Names
epidermal-type fatty acid-binding protein
epithelial fatty acid-binding protein
fatty acid-binding protein, epidermal
keratinocyte lipid-binding protein
psoriasis-associated fatty acid-binding protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272097.1NP_001259026.1  fatty acid-binding protein 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (by one amino acid; isoform 2), compared to isoform 1.
    Source sequence(s)
    AC157379
    Conserved Domains (1) summary
    pfam00061
    Location:9111
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_001272098.1NP_001259027.1  uncharacterized protein LOC16592 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. Variant 3 lacks a large portion of the central coding region found in variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform lacks the lipocalin domain found in isoform 1.
    Source sequence(s)
    AC157379, BE987062, W54445
    Conserved Domains (1) summary
    cl10502
    Location:626
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
  3. NM_010634.3NP_034764.1  fatty acid-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_034764.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC157379, AK011551, BE987062
    Consensus CDS
    CCDS38388.1
    UniProtKB/Swiss-Prot
    Q05816
    UniProtKB/TrEMBL
    Q497I3
    Related
    ENSMUSP00000029046.9, ENSMUST00000029046.9
    Conserved Domains (1) summary
    pfam00061
    Location:9134
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    10077645..10081670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)